Exploring the Association between Hemochromatosis and Lower-Limb Venous Disease.

Autor:	Parker CN; In the School of Nursing, Queensland University of Technology, Queensland, Australia, Christina N. Parker, PhD, is Associate Professor; and Kathleen J. Finlayson, PhD, is Lecturer, Centre for Healthcare Transformation. Emma J. Hall, RN, is Clinical Nurse-Research Coordinator, Gold Coast Hospital and Health Service, Queensland, and Research Project Officer, Queensland University of Technology. Natasha Pitman, RN, is Registered Nurse, Infectious Diseases Unit, Princess Alexandra Hospital, Woolloongabba, Queensland. Wing Kei Chu, BMedLabSc, is Hematology and Blood Bank Scientist, QML Pathology, Murarrie, Queensland. Daniel F. Wallace, PhD, is Associate Professor, Queensland University of Technology. Acknowledgments: The authors acknowledge the valuable contribution of Tony Moorhead and Dianne Prince from Haemochromatosis Australia. The authors have disclosed no financial relationships related to this article. Submitted December 2, 2022; accepted in revised form February 3, 2023., Finlayson KJ, Hall EJ, Pitman N, Chu WK, Wallace DF
Jazyk:	angličtina
Zdroj:	Advances in skin & wound care [Adv Skin Wound Care] 2024 Jan 01; Vol. 37 (1), pp. 32-39.
DOI:	10.1097/ASW.0000000000000080
Abstrakt:	Objective: Chronic venous disease is a circulatory system dysfunction that has the potential to lead to venous leg ulceration. Although research on the influence of specific gene variants on chronic venous disease has been limited, a few studies have reported an association between hemochromatosis and chronic venous disease. However, no studies have looked at the prevalence of lower-limb venous disease and leg ulcers in people with hemochromatosis. This study aimed to review the existing literature for any association between venous disease and hemochromatosis and investigate the prevalence of venous disease and leg ulcers in people with hemochromatosis. Methods: Scoping systematic literature review and cross-sectional study surveying people with hemochromatosis. Results: This scoping systematic literature review included nine articles and indicated a link between hemochromatosis and venous disease/leg ulcers, although further studies are needed to support this link. Analysis of survey results from people with hemochromatosis found a 9.2% prevalence of leg ulcers in those with self-reported hemochromatosis, considerably higher than the 1% to 3% expected, suggesting that hemochromatosis gene variants may be associated with the pathogenesis of chronic venous disease and leg ulcers. Conclusions: This is the first known study to complete a review of the literature regarding hemochromatosis and venous leg ulcers and document the association between hemochromatosis and venous disease/leg ulcers. There is a lack of research in this area and hence limited evidence to guide practice. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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