Premorbid lipid levels and long-term risk of ALS-a population-based cohort study.

Autor:	Vaage AM; Department of Neurology, Akershus University Hospital, Lørenskog, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Benth JŠ; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway., Meyer HE; Department of Physical Health and Ageing, Norwegian Institute of Public Health, Oslo, Norway, and.; Department of Community Medicine and Global Health, University of Oslo, Oslo, Norway., Holmøy T; Department of Neurology, Akershus University Hospital, Lørenskog, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Nakken O; Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
Jazyk:	angličtina
Zdroj:	Amyotrophic lateral sclerosis & frontotemporal degeneration [Amyotroph Lateral Scler Frontotemporal Degener] 2024 May; Vol. 25 (3-4), pp. 358-366. Date of Electronic Publication: 2023 Dec 20.
DOI:	10.1080/21678421.2023.2295455
Abstrakt:	Objective: To assess the temporal relationship between premorbid lipid levels and long-term amyotrophic lateral sclerosis (ALS) risk. Methods: From Norwegian cardiovascular health surveys (1974-2003), we collected information on total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), glucose, and other cardiovascular risk factors. ALS incidence and mortality were identified through validated Norwegian health registries. The relation between premorbid lipid levels and ALS risk was assessed by Cox regression models. Results: Out of 640,066 study participants (51.5% females), 974 individuals (43.5% females) developed ALS. Mean follow-up time was 23.7 (SD 7.1) years among ALS cases. One mmol/l increase in LDL-C was associated with 6% increase in risk for ALS (hazard ratio 1.06 [95% CI: 1.01-1.09]). Higher levels of TC and TG were also associated with increased ALS risk, but only within the last 6-7 years prior to ALS diagnosis or death. No association between HDL-C and ALS risk was found. Adjusting for body mass index, birth cohort, smoking, and physical activity did not alter the results. Conclusions: Higher levels of LDL-C are associated with increased ALS risk over 40 years later, compatible with a causal relationship. The temporal relationship between TG, TC, and ALS risk suggests that increased levels of these lipid biomarkers represent consequences of ALS.
Databáze:	MEDLINE
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