Experimental infection of cattle, sheep, and goats with the newly emerged epizootic hemorrhagic disease virus serotype 8.

Autor: Spedicato M; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Profeta F; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Thabet S; Service de Microbiologie, Immunologie et Pathologie Générale, École Nationale de Médecine Vétérinaire de Sidi Thabet, IRESA, Université de la Manouba, Tunis 2020, Tunisia., Teodori L; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Leone A; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Portanti O; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Pisciella M; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Bonfini B; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Pulsoni S; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Rosso F; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Rossi E; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Ripà P; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., De Rosa A; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Ciarrocchi E; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Irelli R; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Cocco A; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Sailleu C; UMR 1161 Virologie, INRA, ENVA, ANSES, Laboratory for Animal Health, Paris Est University, 94701 Maisons-Alfort, France., Ferri N; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Di Febo T; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Vitour D; UMR 1161 Virologie, INRA, ENVA, ANSES, Laboratory for Animal Health, Paris Est University, 94701 Maisons-Alfort, France., Breard E; UMR 1161 Virologie, INRA, ENVA, ANSES, Laboratory for Animal Health, Paris Est University, 94701 Maisons-Alfort, France., Giansante D; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Sghaier S; Institut de la Recherche Vétérinaire de Tunisie, Tunis 1006, Tunisia., Ben Hassine T; Direction Générale des Services Vétérinaires, Commissariat Régional au Développement Agricole de Nbeul,Nabeul 8000, Tunisia., Zientara S; UMR 1161 Virologie, INRA, ENVA, ANSES, Laboratory for Animal Health, Paris Est University, 94701 Maisons-Alfort, France., Salini R; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Hammami S; Service de Microbiologie, Immunologie et Pathologie Générale, École Nationale de Médecine Vétérinaire de Sidi Thabet, IRESA, Université de la Manouba, Tunis 2020, Tunisia., Savini G; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo-Italy., Lorusso A; IZS Abruzzo e Molise 'G. Caporale', Virology Unit. a.lorusso@izs.it.
Jazyk: angličtina
Zdroj: Veterinaria italiana [Vet Ital] 2023 Dec 31; Vol. 59 (4). Date of Electronic Publication: 2023 Dec 31.
DOI: 10.12834/VetIt.3433.23112.1
Abstrakt: Epizootic hemorrhagic disease virus serotype 8 (EHDV-8) emerged in Europe for the first time in late 2022. In this study, we investigated the kinetics of EHDV-8 infection in cattle, sheep, and goats.  Following experimental infection with EHDV-8, four out of five calves displayed fever, while another calf exhibited ulcerative and crusty lesions of the muzzle. RNAemia peaked at day 7 post infection in all calves and remained relatively stable till the end of the study, at 78 days post infection. Infectious virus was isolated up to 21 days post infection in one calf. As far as small ruminants are concerned, one sheep experienced fever and two out of five had consistent RNAemia that lasted until the end of the study. Remarkably, infectious virus was evidenced at day 7 post infection in one sheep. In goats, no RNA was observed. All infected animals seroconverted, and a neutralizing immune response was observed in all species, with calves exhibiting a more robust response than sheep and goats. Our study provides insights into the kinetics of EHDV-8 infection and the host immune responses. We also highlight that sheep may also play a role in EHDV-8 epidemiology. Altogether, the data gathered in this study could have important implications for disease control and prevention strategies, providing crucial information to policy makers to mitigate the impact of this viral disease on livestock.
Databáze: MEDLINE
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