Increase in antibiotic resistance in diabetic foot infections among peruvian patients: a single-center cross-sectional study.

Autor:	Moya-Salazar J; Faculties of Health Science, Universidad Privada del Norte, Lima, Peru., Chamana JM; Digital Transformation Center, Universidad Norbert Wiener, Lima, Peru., Porras-Rivera D; School of Medicine, Universidad Pedagógica y Tecnológica de Colombia, Tunja, Colombia., Goicochea-Palomino EA; School of Medical Technologist, Faculties of Health Science, Universidad Tecnológica del Perú, Lima, Peru., Salazar CR; Infectious Unit, Nesh Hubbs, Lima, Peru., Contreras-Pulache H; Digital Transformation Center, Universidad Norbert Wiener, Lima, Peru.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Dec 05; Vol. 14, pp. 1267699. Date of Electronic Publication: 2023 Dec 05 (Print Publication: 2023).
DOI:	10.3389/fendo.2023.1267699
Abstrakt:	Background: Diabetic foot is one of the most significant complications in individuals with diabetes and is closely associated with lower limb amputation. The antibiotic susceptibility patterns of these bacterial isolates play a critical role in guiding effective treatment strategies We aimed to determine the most common bacterial agents causing diabetic foot infections in a tertiary-care hospital in Peru. Methods: Clinical and microbiological data were collected from 181 patients diagnosed with diabetic foot infections and positive microbiological culture results. All the samples were analyzed with the Vitek 2 compact system and the cut-off points were defined with the CLSI M100 guide. The data were segregated based on mono-microbial or poly-microbial cultures, bacterial types, and antibiotic susceptibility profiles. Results: A total of 32 bacterial species were identified, predominantly Gram-negative (63%). The most frequent bacterial agents isolated were Staphylococcus aureus (19.9%), Escherichia coli (12.2%), Pseudomonas aeruginosa (8.3%), and Proteus vulgaris (6.6%). These bacteria commonly exhibited resistance to Ampicillin, Ciprofloxacin, Levofloxacin, Trimethoprim-sulfamethoxazole, and Cefuroxime. E. coli showed the highest antibiotic resistance (19 antibiotics), while Gentamicin, Tobramycin, and Levofloxacin demonstrated the highest sensitivity against the most prevalent bacteria. Gram-negative bacteria also exhibited notable antibiotic-susceptibility to Meropenem, Piperacillin/tazobactam, and Amikacin. Regarding the presence of Extended-Spectrum Beta-Lactamase, 54 isolates tested positive, with 35 (64.8%) and 14 (42.4%) of these being S. aureus and E. coli . Conclusions: Bacterial agents causing diabetic foot infections pose a constant concern, particularly due to the increasing antibiotic resistance observed. This difficulty in treating the condition contributes to a higher risk of amputation and mortality. Further research on bacterial susceptibility is necessary to determine appropriate dosages for pharmacological treatment and to prevent the overuse of antibiotics. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Moya-Salazar, Chamana, Porras-Rivera, Goicochea-Palomino, Salazar and Contreras-Pulache.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu