Detection of parechovirus A in respiratory, gastrointestinal, and neurological clinical samples of pediatric patients from Panama (2014-2015).

Autor: Gutierrez L; The University of Texas at El Paso (UTEP), El Paso, TX, 79968, US.; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama., Sáenz V; The University of Texas at El Paso (UTEP), El Paso, TX, 79968, US.; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama., Franco D; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama., Moreno B; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama., Fuentes-Campos E; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama., Capitan-Barrios Z; Facultad de Ciencias Naturales, Exactas y Tecnología, Departamento de Microbiología y Parasitología, Universidad de Panamá, Panamá, Panama.; Carson Centre for Research in Environment and Emerging Infectious Diseases, La Peñita, Darien, Panama., Rivera LF; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama.; Carson Centre for Research in Environment and Emerging Infectious Diseases, La Peñita, Darien, Panama., Carrera JP; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama.; Carson Centre for Research in Environment and Emerging Infectious Diseases, La Peñita, Darien, Panama., Castillo J; Department Research in Genomic and Proteomic, Gorgas Memorial Institute of Health Studies, Panama City, Panama., Castillo M; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama., Pascale JM; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama., López-Vergès S; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama., Sosa N; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama.; Division of Infectious Diseases, University of New Mexico Hospital, Albuquerque, NM, US., Ábrego L; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama. labrego@gorgas.gob.pa.; Facultad de Ciencias Naturales, Exactas y Tecnología, Departamento de Microbiología y Parasitología, Universidad de Panamá, Panamá, Panama. labrego@gorgas.gob.pa.; Carson Centre for Research in Environment and Emerging Infectious Diseases, La Peñita, Darien, Panama. labrego@gorgas.gob.pa.
Jazyk: angličtina
Zdroj: Virology journal [Virol J] 2023 Dec 19; Vol. 20 (1), pp. 302. Date of Electronic Publication: 2023 Dec 19.
DOI: 10.1186/s12985-023-02268-9
Abstrakt: Parechovirus A (PeV-A, Parechovirus, Picornaviridae) are human pathogens associated with mild to severe gastrointestinal and respiratory diseases in young children. While several studies have investigated the association of PeV-A with human disease, little is known about its epidemiology or detection in Latin America. Between the years 2014 and 2015, a total of 200 samples were collected from Panamanian pediatric patients aged < 16 years old exhibiting symptoms associated with respiratory (n = 64), gastrointestinal (n = 68), or neurological (n = 68) diseases. These samples were gathered from patients who had previously received negative diagnoses for the main respiratory viruses, rotavirus, and neurological viruses like herpes virus, enterovirus, and cytomegalovirus. The presence of PeV-A was analyzed by real time RT-PCR.Eight positive PeV-A infections (4.0%, 95% CI: 1.7 to 7.7) were detected: two in respiratory samples (3.0%, 95% CI: 0.3 to 10.8), five in gastrointestinal samples (7.3%, 95% CI: 2.4 to 16.3), and one in cerebrospinal fluid (1.5%, 95% CI: 1.4 to 7.9). The study provides evidence of PeV-A circulation in Panama and the data collectively, remarked on the importance of considering PeV-A in the Panamanian pediatric diagnostic landscape, especially when conventional testing for more common viruses yields negative results.
(© 2023. The Author(s).)
Databáze: MEDLINE
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