Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change.

Autor: Schroeder MN; Laboratorio de Neurofisiología de la Memoria, Instituto de Biología Celular y Neurociencia, Facultad de Medicina (UBA/CONICET) - Instituto Tecnológico de Buenos Aires (ITBA), Ciudad Autónoma de Buenos Aires, Argentina., Fullio CL; Laboratorio de Neurofisiología de la Memoria, Instituto de Biología Celular y Neurociencia 'Prof. E. De Robertis' (IBCN), Facultad de Medicina, UBA-CONICET, Ciudad Autónoma de Buenos Aires, Argentina., Ballarini F; Laboratorio de neurociencia translacional, Instituto de Biología Celular y Neurociencia 'Prof. E. De Robertis' (IBCN), Facultad de Medicina, UBA-CONICET, Ciudad Autónoma de Buenos Aires, Argentina.; Instituto Tecnológico de Buenos Aires, Av. Madero 399, Ciudad Autónoma de Buenos Aires, Argentina., Moncada D; Laboratorio de Neurofisiología de la Memoria, Instituto de Biología Celular y Neurociencia, Facultad de Medicina (UBA/CONICET) - Instituto Tecnológico de Buenos Aires (ITBA), Ciudad Autónoma de Buenos Aires, Argentina. dmoncada@fmed.uba.ar.; Centro Integrativo de Biología y Química Aplicada, Universidad Bernardo O'Higgins, Santiago, Chile. dmoncada@fmed.uba.ar.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2023 Dec 19; Vol. 6 (1), pp. 1288. Date of Electronic Publication: 2023 Dec 19.
DOI: 10.1038/s42003-023-05666-5
Abstrakt: Reconsolidation turns memories into a responsive state that allows their modulation until they stabilize again. This phenomenon attracted remarkable attention due to its potential impact on therapeutics and education. Recent evidence revealed that different memories undergo reconsolidation via a behavioral tagging process. Thus, their re-stabilization involves setting "reconsolidation-tags" and synthesizing plasticity-related proteins for their capture at the tagged sites. Here, we studied the possibility of affecting these fundamental mechanisms to modulate reconsolidation. Our findings, in laboratory rats, indicate that exploring a novel environment 60 min before or after memory reactivation improves spatial object recognition memory by promoting protein synthesis. Conversely, experiencing novelty immediately after reactivation impairs the reconsolidation by affecting the tags. Similar effects, but with a different optimal time window for improvement, occur in inhibitory avoidance memory. These results highlight the possibility of modulating existing memories using non-invasive interventions that selectively affect the fundamental mechanisms of behavioral tagging during their reconsolidation.
(© 2023. The Author(s).)
Databáze: MEDLINE
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