Incidence of bacterial and fungal infections in Polish pediatric patients with acute lymphoblastic leukemia during the pandemic.

Autor: Zawitkowska J; Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, Poland. joannazawitkowska@umlub.pl., Drabko K; Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, Poland., Lejman M; Independent Laboratory of Genetic Diagnostics, Medical University of Lublin, Lublin, Poland., Kowalczyk A; Student Scientific Society of Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, Poland., Czyżewski K; Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland., Dziedzic M; Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland., Jaremek K; Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland., Zalas-Więcek P; Department of Microbiology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland., Szmydki-Baran A; Department of Hematology and Pediatrics, Medical University of Warsaw, Warsaw, Poland., Hutnik Ł; Department of Hematology and Pediatrics, Medical University of Warsaw, Warsaw, Poland., Czogała W; Department of Pediatric Oncology and Hematology, Intitute of Pediatrics, Jagiellonian University Medical College, Kraków, Poland., Balwierz W; Department of Pediatric Oncology and Hematology, Intitute of Pediatrics, Jagiellonian University Medical College, Kraków, Poland., Żak I; Department of Microbiology, University Children's Hospital, Jagiellonian University Medical College, Kraków, Poland., Salamonowicz-Bodzioch M; Department of Pediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, Wroclaw, Poland., Kazanowska B; Department of Pediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, Wroclaw, Poland., Wróbel G; Department of Pediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, Wroclaw, Poland., Frączkiewicz J; Department of Pediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, Wroclaw, Poland., Kałwak K; Department of Pediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, Wroclaw, Poland., Tomaszewska R; Department of Pediatrics, Hematology and Oncology, Medical University of Silesia, Katowice, Poland., Szczepański T; Department of Pediatrics, Hematology and Oncology, Medical University of Silesia, Katowice, Poland., Zając-Spychała O; Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznan, Poland., Wachowiak J; Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznan, Poland., Płonowski M; Department of Pediatric Oncology, Hematology, Medical University of Bialystok, Bialystok, Poland., Krawczuk-Rybak M; Department of Pediatric Oncology, Hematology, Medical University of Bialystok, Bialystok, Poland., Królak A; Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University, Szczecin, Poland., Ociepa T; Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University, Szczecin, Poland., Urasiński T; Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University, Szczecin, Poland., Pierlejewski F; Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Lodz, Poland., Młynarski W; Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Lodz, Poland., Urbańska-Rakus J; Unit of Pediatric Hematology and Oncology, City Hospital, Chorzow, Poland., Machnik K; Unit of Pediatric Hematology and Oncology, City Hospital, Chorzow, Poland., Pająk S; Unit of Pediatric Hematology and Oncology, City Hospital, Chorzow, Poland., Badowska W; Collegium Medicum University of Warmia and Mazury in Olsztyn, Olsztyn, Poland., Brzeski T; Collegium Medicum University of Warmia and Mazury in Olsztyn, Olsztyn, Poland., Mycko K; Collegium Medicum University of Warmia and Mazury in Olsztyn, Olsztyn, Poland., Mańko-Glińska H; Collegium Medicum University of Warmia and Mazury in Olsztyn, Olsztyn, Poland., Urbanek-Dądela A; Department of Pediatric Oncology and Hematology, Collegium Medium of Jan Kochanowski University in Kielce, Kielce, Poland., Karolczyk G; Department of Pediatric Oncology and Hematology, Collegium Medium of Jan Kochanowski University in Kielce, Kielce, Poland., Mizia-Malarz A; Department of Oncology, Hematology and Chemotherapy, Upper Silesia Children's Care Health, Medical University of Silesia, Katowice, Poland., Stolpa W; Department of Oncology, Hematology and Chemotherapy, Upper Silesia Children's Care Health, Medical University of Silesia, Katowice, Poland., Skowron-Kandzia K; Department of Oncology, Hematology and Chemotherapy, Upper Silesia Children's Care Health, Medical University of Silesia, Katowice, Poland., Musiał J; Clinic of Pediatric Oncology and Hematology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland., Chaber R; Clinic of Pediatric Oncology and Hematology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland., Irga-Jaworska N; Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk, Gdańsk, Poland., Bień E; Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk, Gdańsk, Poland., Styczyński J; Student Scientific Society of Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, Poland.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Dec 18; Vol. 13 (1), pp. 22619. Date of Electronic Publication: 2023 Dec 18.
DOI: 10.1038/s41598-023-50093-5
Abstrakt: The most common complications related to the treatment of childhood acute lymphoblastic leukemia (ALL) are infections. The aim of the study was to analyze the incidence and mortality rates among pediatric patients with ALL who were treated in 17 Polish pediatric hematology centers in 2020-2021 during the pandemic. Additionally, we compared these results with those of our previous study, which we conducted in the years 2012-2017. The retrospective analysis included 460 patients aged 1-18 years with newly diagnosed ALL. In our study, 361/460 (78.5%) children were reported to have microbiologically documented bacterial infections during chemotherapy. Ten patients (2.8%) died due to sepsis. Fungal infections were reported in 99 children (21.5%), of whom five (5.1%) died due to the infection. We especially observed an increase in bacterial infections during the pandemic period compared to the previous study. The directions of our actions should be to consider antibiotic prophylaxis, shorten the duration of hospitalization, and educate parents and medical staff about complications (mainly infections) during anticancer therapy. It is necessary to continue clinical studies evaluating infection prophylaxis to improve outcomes in childhood ALL patients.
(© 2023. The Author(s).)
Databáze: MEDLINE
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