Epidemiologic features and outcomes associated with caustic ingestion among adults admitted in intensive care unit from 2013 to 2019: a French national observational study.

Autor: Deniau B; Department of Anaesthesiology, Burn and Critical Care, University Hospitals Saint-Louis-Lariboisière, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France. benjamin.deniau@aphp.fr.; INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Université Paris Cité, Paris, France. benjamin.deniau@aphp.fr.; Université Paris Cité, Paris, France. benjamin.deniau@aphp.fr.; FHU PROMICE, Paris, France. benjamin.deniau@aphp.fr., Boulet N; UR-UM103 IMAGINE, Univ Montpellier, Division of Anesthesia Critical Care, Pain and Emergency Medicine, Nîmes University Hospital, Montpellier, France., Pétrier M; Service de Biostatistique, Epidémiologie Clinique, Santé Publique Innovation et Méthodologie (BESPIM), Pôle Pharmacie, Santé Publique, CHU Nîmes, University of Montpellier, Nîmes, France., Mezzarobba M; Service de Biostatistique, Epidémiologie Clinique, Santé Publique Innovation et Méthodologie (BESPIM), Pôle Pharmacie, Santé Publique, CHU Nîmes, University of Montpellier, Nîmes, France., Coutrot M; Department of Anaesthesiology, Burn and Critical Care, University Hospitals Saint-Louis-Lariboisière, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France., Cattan P; Université Paris Cité, Paris, France.; Service de Chirurgie Viscérale, Cancérologique Et Endocrinienne, Hôpital 13 Saint Louis, Assistance Publique des Hôpitaux de Paris, Université de Paris, Paris, France., Corté H; Service de Chirurgie Viscérale, Cancérologique Et Endocrinienne, Hôpital 13 Saint Louis, Assistance Publique des Hôpitaux de Paris, Université de Paris, Paris, France., Dépret F; Department of Anaesthesiology, Burn and Critical Care, University Hospitals Saint-Louis-Lariboisière, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.; INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Université Paris Cité, Paris, France.; Université Paris Cité, Paris, France.; FHU PROMICE, Paris, France., Lefrant JY; UR-UM103 IMAGINE, Univ Montpellier, Division of Anesthesia Critical Care, Pain and Emergency Medicine, Nîmes University Hospital, Montpellier, France., Plaud B; Department of Anaesthesiology, Burn and Critical Care, University Hospitals Saint-Louis-Lariboisière, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.; INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Université Paris Cité, Paris, France.; Université Paris Cité, Paris, France.; FHU PROMICE, Paris, France., Boudemaghe T; Service Information Médicale, Méthodes Et Recherche (SIMMER), Pôle Pharmacie, Santé Publique, CHU Nîmes, University of Montpellier, Nîmes, France.
Jazyk: angličtina
Zdroj: European journal of trauma and emergency surgery : official publication of the European Trauma Society [Eur J Trauma Emerg Surg] 2024 Jun; Vol. 50 (3), pp. 905-912. Date of Electronic Publication: 2023 Dec 20.
DOI: 10.1007/s00068-023-02392-9
Abstrakt: Purpose: Caustic ingestion is a potential life-threatening condition associated with high morbidity and mortality. Data on patients admitted to Intensive Care Unit (ICU) for severe caustic ingestion are lacking. We aimed to describing epidemiological features and outcomes of patients admitted to ICU for caustic ingestion in France.
Methods: In a retrospective, observational, and multicenter study, data from the national French Programme de Médicalisation des Systèmes d'Informations (PMSI) database were analysed from 2013 to 2019. In-hospital mortality rate (primary outcome) and in-ICU complications (secondary outcomes) were reported and analysed.
Results: 569 patients (289 males (50.8%), with median age of 49 years [interquartile (26-62)] were admitted in 65 French ICU for severe caustic ingestion. Five hundred and thirteen patients (90%) were admitted for intentional caustic ingestion. The median length of stay in ICU was 14.0 [4.0-31.0] days. In-hospital mortality occurred in 56 patients (9.8%). In multivariate analysis, age and simplified acute physiology score II were associated with in-hospital mortality age of 40-59 years [OR = 15.3 (2.0-115.3)], age of 60-79 years [OR = 23.6 (3.1-182.5)], and age > 80 years [OR = 37.0 (4.2-328.6)] and SAPS 2 score [OR = 1.0018 (1.003-1.033), p < 0.001]. During ICU stay, 423 complications (74%) were reported in 505 patients (89%). Infectious (244 (42.9%)), respiratory (207 (36.4%)), surgical 62 (10.9%), haemorrhagic (64 (11.2%)) and thrombo-embolic and (35 (6.2%)) complications were the most frequently reported during ICU stay.
Conclusion: ICU admission for severe caustic ingestion is associated with 9.8% mortality and 74% complications. Age > 40 years and SAPS 2 score were independently associated with mortality.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
Databáze: MEDLINE
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