Inflammatory mediators drive neuroinflammation in autism spectrum disorder and cerebral palsy.

Autor: Than UTT; Vinmec Hi-Tech Center and Vinmec-VinUni Institute of Immunology, Vinmec Healthcare System, Hanoi, 100000, Vietnam. v.uyenttt@vinmec.com., Nguyen LT; Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam.; College of Health Sciences, VinUniversity, Hanoi, 100000, Vietnam., Nguyen PH; Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam., Nguyen XH; Vinmec Hi-Tech Center and Vinmec-VinUni Institute of Immunology, Vinmec Healthcare System, Hanoi, 100000, Vietnam.; Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam.; College of Health Sciences, VinUniversity, Hanoi, 100000, Vietnam., Trinh DP; Faculty of Biology, VNU University of Science, Vietnam National University, Hanoi, Vietnam., Hoang DH; Vinmec Hi-Tech Center and Vinmec-VinUni Institute of Immunology, Vinmec Healthcare System, Hanoi, 100000, Vietnam., Nguyen PAT; Vinmec International Hospital Times City, Vinmec Healthcare System, Hanoi, 100000, Vietnam., Dang VD; Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam. van_duc.dang@drfz.de.; Faculty of Biology, VNU University of Science, Vietnam National University, Hanoi, Vietnam. van_duc.dang@drfz.de.; Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany. van_duc.dang@drfz.de.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Dec 18; Vol. 13 (1), pp. 22587. Date of Electronic Publication: 2023 Dec 18.
DOI: 10.1038/s41598-023-49902-8
Abstrakt: Inflammation conditions are associated with autism spectrum disorder (ASD) and cerebral palsy (CP), primarily observed in the peripheral immune system. However, the extent of neuro-inflammation and neuro-immune dysregulation remains poorly studied. In this study, we analyzed the composition of cerebrospinal fluid (CSF) to uncover the inflammatory mediators driving the neuro-immune system in ASD and CP patients. Our findings revealed that ASD patients had elevated levels of four inflammatory cytokines (TNF-α, IL-4, IL-21, and BAFF) compared to controls, while CP patients exhibited increased levels of eight inflammatory cytokines (IFN-γ, GM-CSF, TNF-α, IL-2, IL-4, IL-6, IL-17A and IL-12), one anti-inflammatory cytokine (IL-10), and five growth factors (GFs) (NGF-β, EGF, GDF-15, G-CSF and BMP-9) compared to both controls and ASD patients. Additionally, intrathecal infusion of autologous bone marrow mononuclear cells (BMMNCs) led to a slight decrease in TGF-β and GDF-15 levels in the CSF of ASD and CP patients, respectively. Our study provides new insights into the molecular composition of CSF in ASD and CP patients, with the potential to develop more effective diagnosis methods and improved treatment for these diseases.Clinical trial registration CSF samples used in this study are from clinical trials NCT03225651, NCT05307536, NCT02569775, NCT03123562, NCT02574923, NCT05472428 and previous reports [7, 9, 17-19].
(© 2023. The Author(s).)
Databáze: MEDLINE
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