Correlation between serum vitamin D level and uterine volume in girls with idiopathic central precocious puberty.

Autor:	Sun J; The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China., Wang W; The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China., Xiao Y; The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China., Cao NN; The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China., Wang YF; The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China., Zhang HR; The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China., Jiang SQ; The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China.
Jazyk:	angličtina
Zdroj:	Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2023 Dec 21; Vol. 37 (2), pp. 144-149. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2024).
DOI:	10.1515/jpem-2023-0381
Abstrakt:	Objectives: Investigate serum vitamin D (vit D) levels' relation to uterine volume in idiopathic central precocious puberty (ICPP) girls and compare findings with normal peers. Methods: Analyzed 278 ICPP cases from January 2017 to September 2022 alongside 239 normally developing girls. Collected clinical data and lab markers and performed subgroup analysis based on vit D levels. Correlation and regression analyses were conducted. Results: The ICPP group exhibited elevated uterine volume and lower serum vit D compared to controls (p<0.05). A weak negative correlation was noted between vit D and uterine volume in ICPP (r=-0.193, p=0.004), and no such correlation in controls (r=-0.073, p=0.319). The ICPP vit D deficiency subgroup displayed higher uterine volume than the insufficiency and sufficiency subgroups (p<0.05). Uterine volume in the insufficiency subgroup exceeded the sufficiency subgroup (p<0.05). After adjusting for confounders, lower vit D is linked to increased ICPP uterine volume (non-standardized regression coefficient β=-25.55, 95 % CI= -46.23, -4.87, p=0.016). A Limited correlation between vit D and uterine volume was seen in girls with normal pubertal timing. Conclusions: We demonstrated a correlation between vit D and uterine volume in ICPP girls, absent in normal peers. ICPP girls often exhibit lower vit D levels and increased uterine volume. Further research is vital for understanding vit D's role in ICPP pathogenesis and guiding prevention and treatment strategies. (© 2023 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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