A first-in-human pilot study of a novel electrically-passive metamaterial-inspired resonator-based ocular sensor embedded contact lens monitoring intraocular pressure fluctuations.

Autor: Kaya O; Glakolens, Bogazici Universitesi Teknopark 302, 34470 Istanbul, Turkiye., Akif Aydin M; Glakolens, Bogazici Universitesi Teknopark 302, 34470 Istanbul, Turkiye., Teymoori M; Glakolens, Bogazici Universitesi Teknopark 302, 34470 Istanbul, Turkiye., Kaan Erden O; Glakolens, Bogazici Universitesi Teknopark 302, 34470 Istanbul, Turkiye., Sadeghzadeh S; Glakolens, Bogazici Universitesi Teknopark 302, 34470 Istanbul, Turkiye., Dedeoglu UO; Glakolens, Bogazici Universitesi Teknopark 302, 34470 Istanbul, Turkiye., Demir S; Glakolens, Bogazici Universitesi Teknopark 302, 34470 Istanbul, Turkiye., Muhikanci O; Glakolens, Bogazici Universitesi Teknopark 302, 34470 Istanbul, Turkiye., Sahin A; Department of Ophthalmology, Koc University Medical School, Istanbul, Turkiye., Torun H; Faculty of Engineering & Environment, University of Northumbria, Newcastle Upon Tyne, NE1 8ST, UK. Electronic address: hamdi.torun@northumbria.ac.uk., Dundar G; Department of Electrical and Electronics Engineering, Bogazici University, Bebek 34342 Istanbul, Turkiye., Yalcinkaya AD; Department of Electrical and Electronics Engineering, Bogazici University, Bebek 34342 Istanbul, Turkiye.
Jazyk: angličtina
Zdroj: Contact lens & anterior eye : the journal of the British Contact Lens Association [Cont Lens Anterior Eye] 2024 Apr; Vol. 47 (2), pp. 102102. Date of Electronic Publication: 2023 Dec 19.
DOI: 10.1016/j.clae.2023.102102
Abstrakt: Glaucoma is a leading cause of blindness with no cure, but early treatment and effective monitoring can often slow the progression of the disease. Monitoring of glaucoma is based on the measurement of intra-ocular pressure (IOP) that is a physiological parameter related to the mechanical state and parameters of the eye. Conventionally, diagnosing and assessing the progression of glaucoma is based on the method of measuring IOP discretely at clinics. Recent studies have demonstrated the importance of continuously monitoring IOP for 24 h to elucidate the effect of circadian rhythm. In this work, a metamaterial-inspired electrically-passive sensor-embedded contact lens is presented to monitor the IOP fluctuations based on a first-in-human pilot study. The sensor inside the contact lens is an electrically passive, metamaterial-based resonator that can be measured using a wearable antenna patch. The system has been tested with six healthy volunteers during an experiment to induce deliberate IOP changes via water-loading and placing the individuals in supine position using a recliner seat. The initial data compared with tonometer measurements suggest that the system can be used to assess the variation of IOP continuously.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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