Influence of sex on the persistence of different classes of targeted therapies for psoriatic arthritis: a cohort study of 14 778 patients from the French health insurance database (SNDS).
| Autor: | Pina Vegas L; EpiDermE, Université Paris-Est Créteil Val de Marne, Créteil, France.; Service de Rhumatologie, Hopital Henri Mondor, Créteil, France., Penso L; EpiDermE, Université Paris-Est Créteil Val de Marne, Créteil, France., Sbidian E; EpiDermE, Université Paris-Est Créteil Val de Marne, Créteil, France.; Inserm, Centre d'investigation clinique 1430, Hopital Henri Mondor, Créteil, France., Claudepierre P; EpiDermE, Université Paris-Est Créteil Val de Marne, Créteil, France pascal.claudepierre@aphp.fr.; Service de Rhumatologie, Hopital Henri Mondor, Créteil, France. |
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| Jazyk: | angličtina |
| Zdroj: | RMD open [RMD Open] 2023 Dec 19; Vol. 9 (4). Date of Electronic Publication: 2023 Dec 19. |
| DOI: | 10.1136/rmdopen-2023-003570 |
| Abstrakt: | Background: Sex differences in phenotype presentation, disease trajectory and treatment response in psoriatic arthritis (PsA) have been reported. Nevertheless, whether classes of targeted therapies differentially affect men and women with PsA remains unclear. Objectives: To assess the effect of sex on the long-term persistence of each class of targeted therapies in PsA. Methods: This nationwide cohort study involved the administrative healthcare database of the French health insurance scheme linked to the hospital discharge database. We included all adults with PsA who were new users of targeted therapies (not in the year before the index date) during 2015-2021 and studied all treatment lines during the study period. Persistence was defined as the time from treatment initiation to discontinuation and was estimated by the Kaplan-Meier method. Comparison of persistence by sex involved multivariate frailty models with conventional synthetic disease-modifying antirheumatic drugs and prednisone as time-dependant variables. Results: We included 14 778 patients with PsA who were new users of targeted therapies: 8475 (57%) women (mean age 50±13 years; 15 831 lines), 6303 (43%) men (mean age 51±13 years; 10 488 lines). Overall, 1-year persistence was 52% for women and 62% for men and at 3 years it was 27% and 39%, respectively. After adjustments, persistence was lower for women than men for inhibitors of tumour necrosis factor (TNFi) (adjusted HR (HR Conclusion: The treatment persistence was lower for women than men for TNFi and IL17i but not for IL12/23i, IL23i or JAKi. Competing Interests: Competing interests: LPV received a subsidy from Novartis to attend a congress. LP and ES have no conflict of interest to declare. PC has received consulting fees from Abbvie, Amgen, Pfizer, Roche-Chugai, BMS, MSD, UCB, Novartis, Janssen, Lilly, Galapagos, Celgene (less than US$10 000 each) and has been an investigator for Roche Chugai, Sanofi Aventis, Celgene, Pfizer, MSD, Novartis and BMS. (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Databáze: | MEDLINE |
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