| Autor: |
Benton D; Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA., Chernoff J; Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Science signaling [Sci Signal] 2023 Dec 19; Vol. 16 (816), pp. eadk9171. Date of Electronic Publication: 2023 Dec 19. |
| DOI: |
10.1126/scisignal.adk9171 |
| Abstrakt: |
Oncogenic small guanosine triphosphatases (GTPases) are often characterized by a limited set of activating mutations that affect their intrinsic biochemical function, but RHOA-which is frequently mutated in gastric cancer-appears not to have read the instruction manual. Having previously characterized the Y42C RHOA mutation in gastric cancer, in this issue of Science Signaling , Schaefer et al. take on the slightly less common L57V mutation and find that individual RHOA mutations can have different and unpredictable signaling outcomes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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