Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma.
Autor: | Mohamed MF; Department of Chemistry, College of Science and Arts at Khaulis, University of Jeddah, Jeddah, Saudi Arabia. magdafikry85@yahoo.com.; Department of Chemistry (Biochemistry Branch), Faculty of Science, Cairo University, Giza, Egypt. magdafikry85@yahoo.com., Ibrahim NS; Department of Chemistry (Biochemistry Branch), Faculty of Science, Cairo University, Giza, Egypt., Saddiq AA; Department of Biology, College of Science and Arts at Khaulis, University of Jeddah, Jeddah, Saudi Arabia., Abdelhamid IA; Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt. ismail_shafy@cu.edu.eg. |
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Jazyk: | angličtina |
Zdroj: | Scientific reports [Sci Rep] 2023 Dec 15; Vol. 13 (1), pp. 22486. Date of Electronic Publication: 2023 Dec 15. |
DOI: | 10.1038/s41598-023-48494-7 |
Abstrakt: | A novel series of α-cyano indolylchalcones was prepared, and their chemical structures were confirmed based on the different spectral data. Among them, compound 7f was observed to be the most effective bioactive chalcone with distinguished potency and selectivity against colorectal carcinoma (HCT (© 2023. The Author(s).) |
Databáze: | MEDLINE |
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