Anemia and Optimal Transfusion Thresholds in Brain-Injured Patients: A Narrative Review of the Literature.
| Autor: | Ma K; From the Department of Anesthesiology and Pain Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada., Bebawy JF; Department of Anesthesiology and Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois. |
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| Jazyk: | angličtina |
| Zdroj: | Anesthesia and analgesia [Anesth Analg] 2024 May 01; Vol. 138 (5), pp. 992-1002. Date of Electronic Publication: 2023 Dec 18. |
| DOI: | 10.1213/ANE.0000000000006772 |
| Abstrakt: | Anemia is a highly prevalent condition that may compromise oxygen delivery to vital organs, especially among the critically ill. Although current evidence supports the adoption of a restrictive transfusion strategy and threshold among the nonbleeding critically ill patient, it remains unclear whether this practice should apply to the brain-injured patient, given the predisposition to cerebral ischemia in this patient population, in which even nonprofound anemia may exert a detrimental effect on clinical outcomes. The purpose of this review is to provide an overview of the pathophysiological changes related to impaired cerebral oxygenation in the brain-injured patient and to present the available evidence on the effect of anemia and varying transfusion thresholds on the clinical outcomes of patients with acute brain injury. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2023 International Anesthesia Research Society.) |
| Databáze: | MEDLINE |
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