Influence of Microbiota on Clinical Expressions of Respiratory Viral Infections.

Autor:	Diouf FS; VITROME IRD, Campus International de Recherche IRD-UCAD Hann, Dakar, Senegal.; Aix Marseille Université, Institut de recherche pour le développement, Assistance Publique - Hôpitaux de Marseille, Microbes, Évolution, Phylogénie et Infection, Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France., Tidjani Alou M; Aix Marseille Université, Institut de recherche pour le développement, Assistance Publique - Hôpitaux de Marseille, Microbes, Évolution, Phylogénie et Infection, Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France., Million M; Aix Marseille Université, Institut de recherche pour le développement, Assistance Publique - Hôpitaux de Marseille, Microbes, Évolution, Phylogénie et Infection, Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France., Diatta G; VITROME IRD, Campus International de Recherche IRD-UCAD Hann, Dakar, Senegal., Goumballa N; VITROME IRD, Campus International de Recherche IRD-UCAD Hann, Dakar, Senegal.; Aix-Marseille Université, Institut de recherche pour le développement, Assistance Publique-Hôpitaux de Marseille, Service de santé des armées, Vecteurs - Infections Tropicales et Méditerranéennes, Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France., Ndiaye D; VITROME IRD, Campus International de Recherche IRD-UCAD Hann, Dakar, Senegal., Bassene H; VITROME IRD, Campus International de Recherche IRD-UCAD Hann, Dakar, Senegal., Dubourg G; Aix Marseille Université, Institut de recherche pour le développement, Assistance Publique - Hôpitaux de Marseille, Microbes, Évolution, Phylogénie et Infection, Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France., Raoult D; Aix Marseille Université, Institut de recherche pour le développement, Assistance Publique - Hôpitaux de Marseille, Microbes, Évolution, Phylogénie et Infection, Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France., Sokhna C; VITROME IRD, Campus International de Recherche IRD-UCAD Hann, Dakar, Senegal.; Aix Marseille Université, Institut de recherche pour le développement, Assistance Publique - Hôpitaux de Marseille, Microbes, Évolution, Phylogénie et Infection, Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France., Lagier JC; Aix Marseille Université, Institut de recherche pour le développement, Assistance Publique - Hôpitaux de Marseille, Microbes, Évolution, Phylogénie et Infection, Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France.
Jazyk:	angličtina
Zdroj:	The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2023 Dec 18; Vol. 110 (2), pp. 391-398. Date of Electronic Publication: 2023 Dec 18 (Print Publication: 2024).
DOI:	10.4269/ajtmh.23-0244
Abstrakt:	Respiratory infections, mainly due to viruses, are among the leading causes of worldwide morbidity and mortality. We investigated the prevalence of viruses and bacteria in a cross-sectional survey conducted in Dielmo, a village in rural Senegal with a population of 481 inhabitants. Nasopharyngeal sampling was performed in 50 symptomatic subjects and 101 asymptomatic subjects. Symptomatic subjects were defined as individuals presenting with clinical signs of respiratory infection, whereas asymptomatic subjects were recruited in the same households. The identification of pathogens was performed by polymerase chain reaction for 18 respiratory viruses and eight respiratory bacteria. The prevalence results for respiratory viruses detected in each study group demonstrated that 83.6% of symptomatic samples were positive for at least one respiratory virus, and 21.8% were detected in asymptomatic samples. Influenza A (P = 0.0001), metapneumovirus (P = 0.04), and enterovirus (P = 0.001) were significantly more prevalent in symptomatic patients. Overall, 82.0% of symptomatic subjects and 26.9% of asymptomatic subjects were positive for at least one respiratory bacterium. The most frequent pathogenic bacteria detected were Moraxella catarrhalis (56%) and Streptococcus pneumoniae (48.0%) among symptomatic individuals, whereas in asymptomatic subjects Corynebacterium propinquum was more prevalent (18%). A principal component analysis showed that parainfluenzas 2 and 4 were associated with asymptomatic subjects, whereas influenza A was associated with the presence of symptoms. Considering these results, a large epidemiological surveillance of the circulation of these respiratory pathogens in the general population should be conducted to provide a better understanding of their carriage and to potentially prevent epidemics.
Databáze:	MEDLINE
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