Comorbid Conditions in a Cohort of Inpatients with SARS-CoV-2 and their Association with In-Hospital Mortality During the Early Phases of the Pandemic.

Autor:	Dokic D; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 2PHI University Clinic for Pulmonology and Allergology, Skopje, RN Macedonia., Cibrev D; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 3PHI University Clinic for Neurology, Skopje, RN Macedonia., Danilovski D; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 4Institute for Epidemiology, Biostatistics and Medical informatics, Skopje, RN Macedonia., Chamurovski N; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 5Institute for Tuberculosis and Respiratory Diseases, Skopje, RN Macedonia., Karajovanov ID; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 6PHI University Clinic for Dermatology, Skopje, RN Macedonia., Karanfilovski V; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 7PHI University Clinic for Nephrology, Skopje, RN Macedonia., Stefanovski G; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 8PHI University Clinic for Gastroenterohepatology, Skopje, RN Macedonia., Klenkoski S; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 9PHI University Clinic for Eye Diseases, Skopje, RN Macedonia., Arnautovska B; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 10PHI University Clinic for ORL, Skopje, RN Macedonia., Barbov I; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 3PHI University Clinic for Neurology, Skopje, RN Macedonia., Zeynel S; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 5Institute for Tuberculosis and Respiratory Diseases, Skopje, RN Macedonia., Stardelova KG; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 8PHI University Clinic for Gastroenterohepatology, Skopje, RN Macedonia., Rambabova-Bushljetik I; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 7PHI University Clinic for Nephrology, Skopje, RN Macedonia., Nikolovska S; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 6PHI University Clinic for Dermatology, Skopje, RN Macedonia., Netkovski J; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 10PHI University Clinic for ORL, Skopje, RN Macedonia., Duma H; 1Medical Faculty, Saints Cyril and Methodius University in Skopje, Skopje, RN Macedonia.; 9PHI University Clinic for Eye Diseases, Skopje, RN Macedonia.
Jazyk:	angličtina
Zdroj:	Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) [Pril (Makedon Akad Nauk Umet Odd Med Nauki)] 2023 Dec 18; Vol. 44 (3), pp. 27-39. Date of Electronic Publication: 2023 Dec 18 (Print Publication: 2023).
DOI:	10.2478/prilozi-2023-0044
Abstrakt:	Introduction : Studies determined that age and associated comorbidities are associated with worse outcomes for COVID-19 patients. The aim of the present study is to examine previous electronic health records of SARS-CoV-2 patients to identify which chronic conditions are associated with in-hospital mortality in a nationally representative sample. Materials and Methods : The actual study is a cross-sectional analysis of SARS-CoV-2 infected patients who were treated in repurposed hospitals. The study includes a cohort of patients treated from 06-11-2020 to 15-03-2021 for COVID-19 associated pneumonia. To examine the presence of comorbidities, electronic health records were examined and analyzed. Results : A total of 1486 in-patients were treated in the specified period, out of which 1237 met the criteria for case. The median age of the sample was 65 years. The overall in-hospital mortality in the sample was 25.5%, while the median length of stay was 11 days. From whole sample, 16.0% of the patients did not have established diagnoses in their electronic records, while the most prevalent coexisting condition was arterial hypertension (62.7%), followed by diabetes mellitus (27.3%). The factors of age, male gender, and the number of diagnoses showed a statistically significant increase in odds ratio (OR) for in-hospital mortality. The presence of chronic kidney injury was associated with the highest increase of OR (by 3.37) for in-hospital mortality in our sample. Conclusion : The study reaffirms the findings that age, male gender, and the presence of comorbidities are associated with in-hospital mortality in COVID-19 treated and unvaccinated patients. Our study suggests that chronic kidney injury showed strongest association with the outcome, when adjusted for age, gender, and coexisting comorbidities. (© 2023 Dejan Dokic et al., published by Sciendo.)
Databáze:	MEDLINE
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