Anticancer Potential of β-Carboline Alkaloids: An Updated Mechanistic Overview.

Autor: Tshikhudo PP; Department of Agriculture, Land Reform and Rural Development, Directorate Plant Health, Division Pest Risk Analysis, Arcadia, Pretoria, South Africa., Mabhaudhi T; Centre for Transformative Agricultural and Food Systems, School of Agricultural, Earth and Environmental Sciences, University of KwaZulu-Natal, P. Bag X01, Scottsville, 3209, Pietermaritzburg, South Africa., Koorbanally NA; School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa., Mudau FN; School of Agricultural, Earth and Environmental Sciences, University of KwaZulu-Natal, P. Bag X01, Scottsville, 3209, Pietermaritzburg, South Africa., Avendaño Caceres EO; Departamento de quimica e ingenieria Quimica, Universidad Nacional Jorge Basadre Grohmann. Avenida Miraflores s/n, Tacna, 23001, Perú., Popa D; Department of Plastic Surgery, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania., Calina D; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania., Sharifi-Rad J; Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Feb; Vol. 21 (2), pp. e202301263. Date of Electronic Publication: 2024 Jan 15.
DOI: 10.1002/cbdv.202301263
Abstrakt: his comprehensive review is designed to evaluate the anticancer properties of β-carbolines derived from medicinal plants, with the ultimate goal of assessing their suitability and potential in cancer treatment, management, and prevention. An exhaustive literature survey was conducted on a wide array of β-carbolines including, but not limited to, harmaline, harmine, harmicine, harman, harmol, harmalol, pinoline, tetrahydroharmine, tryptoline, cordysinin C, cordysinin D, norharmane, and perlolyrine. Various analytical techniques were employed to identify and screen these compounds, followed by a detailed analysis of their anticancer mechanisms. Natural β-carbolines such as harmaline and harmine have shown promising inhibitory effects on the growth of cancer cells, as evidenced by multiple in vitro and in vivo studies. Synthetically derived β-carbolines also displayed noteworthy anticancer, neuroprotective, and cognitive-enhancing effects. The current body of research emphasizes the potential of β-carbolines as a unique source of bioactive compounds for cancer treatment. The diverse range of β-carbolines derived from medicinal plants can offer valuable insights into the development of new therapeutic strategies for cancer management and prevention.
(© 2023 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
Externí odkaz: