Gene-environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding.

Autor:	Klingenberg B; Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands., Guloksuz S; Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands.; Department of Psychiatry, Yale School of medicine, USA., Pries LK; Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands., Cinar O; Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands., Menne-Lothmann C; Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands., Decoster J; Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands.; University Psychiatric Centre, KU Leuven, Belgium., van Winkel R; Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands.; University Psychiatric Centre, KU Leuven, Belgium., Collip D; Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands., Delespaul P; Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands., De Hert M; University Psychiatric Centre, KU Leuven, Belgium.; Antwerp Health Law and Ethics Chair, AHLEC University Antwerpen, Antwerp, Belgium., Derom C; Centre of Human Genetics, University Hospitals Leuven, Belgium.; Department of Obstetrics and Gynaecology, Ghent University Hospitals, Belgium., Thiery E; Department of Neurology, Ghent University Hospitals, Belgium., Jacobs N; Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands.; Faculty of Psychology and Educational Sciences, Open University of the Netherlands, The Netherlands., Wichers M; Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands.; Department of Psychiatry, University Medical Center Groningen, The Netherlands.; The Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), The Netherlands., Lin BD; Brain Centre Rudolf Magnus, University Medical Center Utrecht, The Netherlands., Luykx J; Brain Centre Rudolf Magnus, University Medical Center Utrecht, The Netherlands., van Os J; Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands.; Brain Centre Rudolf Magnus, University Medical Center Utrecht, The Netherlands.; King's College London, King's Health Partners, Department of Psychosis Studies, Institute of Psychiatry, UK., Rutten BPF; Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands.
Jazyk:	angličtina
Zdroj:	Personality neuroscience [Personal Neurosci] 2023 Aug 04; Vol. 6, pp. e5. Date of Electronic Publication: 2023 Aug 04 (Print Publication: 2023).
DOI:	10.1017/pen.2023.2
Abstrakt:	The present study examines whether neuroticism is predicted by genetic vulnerability, summarized as polygenic risk score for neuroticism (PRS N ), in interaction with bullying, parental bonding, and childhood adversity. Data were derived from a general population adolescent and young adult twin cohort. The final sample consisted of 202 monozygotic and 436 dizygotic twins and 319 twin pairs. The Short Eysenck Personality questionnaire was used to measure neuroticism. PRS N was trained on the results from the Genetics of Personality Consortium (GPC) and United Kingdom Biobank (UKB) cohorts, yielding two different PRS N . Multilevel mixed-effects models were used to analyze the main and interacting associations of PRS N , childhood adversity, bullying, and parental bonding style with neuroticism. We found no evidence of gene-environment correlation. PRS N thresholds of .005 and .2 were chosen, based on GPC and UKB datasets, respectively. After correction for confounders, all the individual variables were associated with the expression of neuroticism: both PRS N from GPC and UKB, childhood adversity, maternal bonding, paternal bonding, and bullying in primary school and secondary school. However, the results indicated no evidence for gene-environment interaction in this cohort. These results suggest that genetic vulnerability on the one hand and negative life events (childhood adversity and bullying) and positive life events (optimal parental bonding) on the other represent noninteracting pathways to neuroticism. Competing Interests: The authors have no relevant financial or nonfinancial interests to disclose. (© The Author(s) 2023.)
Databáze:	MEDLINE
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