Fabrication of ethosuximide loaded alginate/polyethylene oxide scaffolds for epilepsy research using 3D-printing method.
| Autor: | Karabulut H; Department of Systems Science and Industrial Engineering, State University of New York at Binghamton, Binghamton, NY, United States.; Center for Nanotechnology and Biomaterials Application and Research, Marmara University, Istanbul, Türkiye., Dutta A; UCL Division of Surgery and Interventional Sciences, Royal Free Hospital Campus, London, United Kingdom., Moukbil Y; Center for Nanotechnology and Biomaterials Application and Research, Marmara University, Istanbul, Türkiye.; School of Medicine and Psychology, College of Health and Medicine, Australian National University, Canberra, ACT, Australia., Cisen Akyol A; Center for Nanotechnology and Biomaterials Application and Research, Marmara University, Istanbul, Türkiye.; Department of Bioengineering, Graduate School of Natural and Applied Sciences, Yildiz Technical University, Istanbul, Türkiye., Ulag S; Center for Nanotechnology and Biomaterials Application and Research, Marmara University, Istanbul, Türkiye.; Department of Metallurgy and Materials Engineering, Faculty of Technology, Marmara University, Istanbul, Türkiye., Aydin B; Department of Biophysics, School of Medicine, Marmara University, Istanbul, Türkiye., Gulhan R; Department of Medical Pharmacology, School of Medicine, Marmara University, Istanbul, Türkiye.; Epilepsy Research and Implementation Center, Marmara University, Istanbul, Türkiye., Us Z; Department of Medical Pharmacology, School of Medicine, Marmara University, Istanbul, Türkiye., Kalaskar DM; UCL Division of Surgery and Interventional Sciences, Royal Free Hospital Campus, London, United Kingdom., Gunduz O; Center for Nanotechnology and Biomaterials Application and Research, Marmara University, Istanbul, Türkiye.; Department of Metallurgy and Materials Engineering, Faculty of Technology, Marmara University, Istanbul, Türkiye. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2023 Dec 01; Vol. 11, pp. 1244323. Date of Electronic Publication: 2023 Dec 01 (Print Publication: 2023). |
| DOI: | 10.3389/fbioe.2023.1244323 |
| Abstrakt: | Epilepsy is a medical condition that causes seizures and impairs the mental and physical activities of patients. Unfortunately, over one-third of patients do not receive adequate relief from oral Antiepileptic Drugs (AEDs) and continue to experience seizures. In addition to that, long term usage of Antiepileptic Drugs can cause a range of side effects. To overcome this problem, the precision of 3D printing technology is combined with the controlled release capabilities of biodegradable polymers, allowing for tailored and localized AED delivery to specific seizure sites. As a result of this novel technique, therapeutic outcomes can be enhanced, side effects of AEDs are minimized, and patient-specific dosage forms can be created. This study focused on the use of ethosuximide, an antiepileptic drug, at different concentrations (10, 13, and 15 mg) loaded into 3D-printed sodium alginate and polyethylene oxide scaffolds. The scaffolds contained varying concentrations (0.25%, 0.50%, and 0.75% w/v) and had varying pores created by 3D patterning sizes from 159.86 ± 19.9 µm to 240.29 ± 10.7 µm to optimize the releasing system for an intracranial administration. The addition of PEO changed the T Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Karabulut, Dutta, Moukbil, Cisen Akyol, Ulag, Aydin, Gulhan, Us, Kalaskar and Gunduz.) |
| Databáze: | MEDLINE |
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