Carbapenemase genes distribution in clonal lineages of Acinetobacter baumannii : a comprehensive study on plasmids and chromosomes.
Autor: | Beig M; Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran., Badmasti F; Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran., Solgi H; Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Nikbin VS; Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran., Sholeh M; Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran. |
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Jazyk: | angličtina |
Zdroj: | Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Dec 01; Vol. 13, pp. 1283583. Date of Electronic Publication: 2023 Dec 01 (Print Publication: 2023). |
DOI: | 10.3389/fcimb.2023.1283583 |
Abstrakt: | Background: The global spread of plasmids carrying carbapenemase genes within carbapenem resistant Acinetobacter baumannii (CRAB) strains poses a worldwide public health issue. In this study, we conducted a comprehensive genetic analysis of plasmids and chromosomes harboring the major carbapenemase genes ( bla Methods: We retrieved plasmids and chromosomes carrying the major carbapenemase genes from GenBank. The size, replicon type, and conjugal apparatus of the plasmids were also determined. Furthermore, allele types, co-existence of other antimicrobial resistance genes alongside carbapenemases in plasmids or chromosomes, co-occurrence of carbapenemase genes, gene repetition, and sequence types (ST) of whole genomes were characterized. Results: The database contained 113 plasmids and 38 chromosomes harboring carbapenemase genes. This investigation revealed that bla Conclusion: A. baumannii appears to have a strong ability for genome plasticity to incorporate carbapenemase genes on its plasmids and chromosomes to develop resistance against carbapenems. Mobilizable plasmids harboring carbapenemases significantly contribute to the dissemination of these genes. The genetic structure of the plasmids revealed a strong associations of class I integrons, IS Aba -like structures, Tn 4401 elements, and aac (6')-Ib with carbapenemases. Furthermore, gene repetition may also be associated with carbapenem heteroresistance. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Beig, Badmasti, Solgi, Nikbin and Sholeh.) |
Databáze: | MEDLINE |
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