Trends and cardiovascular outcomes of Takotsubo syndrome with cardiogenic shock vs. mixed cardiogenic and septic shock: a nationwide propensity matched analysis.

Autor:	Fakhra S; Department of Internal Medicine, University of Nevada, Reno, NV, USA., Faisaluddin M; Department of Internal Medicine, Rochester General Hospital, Rochester, NY, USA., Sattar Y; Department of Cardiology, West Virginia University, Morgantown, WV, USA., DeCicco D; Department of Cardiology, West Virginia University, Morgantown, WV, USA., Ahmed A; Department of Internal Medicine, Rochester General Hospital, Rochester, NY, USA., Patel N; Department of Internal Medicine, New York Medical College/Landmark Medical Center, Woonsocket, RI, USA., Balasubramanian S; Division of Cardiovascular Medicine, NorthShore University Health System-Metro Chicago, Evanston, IL, USA., Ludhwani D; Department of Cardiology, West Virginia University, Morgantown, WV, USA., Masood H; Department of Critical Care, Pakistan Railway Hospital, Rawalpindi, Pakistan., Raina S; Department of Cardiology, West Virginia University, Morgantown, WV, USA., Gonuguntla K; Department of Cardiology, West Virginia University, Morgantown, WV, USA., Feitell SC; Department Of Cardiology, Rochester General Hospital, Rochester, NY, USA., Tarun T; Division of cardiovascular medicine, University of Arkansas School of Medicine, Little Rock, AR, USA., Balla S; Department of Cardiology, West Virginia University, Morgantown, WV, USA.
Jazyk:	angličtina
Zdroj:	Expert review of cardiovascular therapy [Expert Rev Cardiovasc Ther] 2024 Jan-Mar; Vol. 22 (1-3), pp. 103-109. Date of Electronic Publication: 2023 Dec 18.
DOI:	10.1080/14779072.2023.2295378
Abstrakt:	Introduction: Takotsubo syndrome (TTS), also known as stress-induced cardiomyopathy, can be complicated by shock. The outcomes of patients with TTS complicated with cardiogenic shock (CS) versus mixed cardiogenic and septic shock (MS) is not known. Methods: We queried Nationwide Inpatient Sample (NIS) from 2009-2020 to compare TTS patients with CS and MS using International Classification of Disease, Ninth & Tenth Edition, Clinical Modification (ICD- 9 & 10-CM) coding. In-hospital outcomes were compared using one: one propensity score matched (PSM) analysis. The primary outcome was in-hospital mortality. Results: Of 23,126 patients with TTS 17,132 (74%) had CS, and 6,269 (26%) had MS. The mean age was 67 years in CS and 66 years in MS, and majority of patients were female ( n  = 17,775, 77%). On adjusted multivariate analysis, MS patients had higher odds of in-hospital mortality (aOR 1.44, 95% CI 1.36-1.52), AKI (aOR 1.53, 95% CI 1.48-1.58), pressor requirement (aOR 1.37, 95% CI 1.25-1.50). However, had lower odds of MCS use (aOR 0.44, 95% CI 0.40-0.48) and cardiac arrest (aOR: 0.81, 95% CI 0.73-0.90) (p-value <0.0001). Mean LOS and inflation-adjusted hospital charges were higher in MS. Conclusion: MS in the setting of TTS have higher rates of in-hospital mortality, AKI, and pressor requirements.
Databáze:	MEDLINE
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