Soft ferroelectret ultrasound receiver for targeted peripheral neuromodulation.

Autor: Li T; School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.; Department of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China.; Research Center for Nature-inspired Engineering, City University of Hong Kong, Hong Kong, 999077, China., Wei Z; School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China., Jin F; School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China., Yuan Y; Department of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China., Zheng W; School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China., Qian L; School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China., Wang H; Department of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China., Hua L; Department of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China.; Department of Anaesthesiology, The University of Hong Kong, Hong Kong, 999077, China., Ma J; School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China., Zhang H; Department of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China., Gu H; Department of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China., Irwin MG; Department of Anaesthesiology, The University of Hong Kong, Hong Kong, 999077, China., Wang T; State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China. tingwang@seu.edu.cn., Wang S; Department of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China. steven.wang@cityu.edu.hk.; Research Center for Nature-inspired Engineering, City University of Hong Kong, Hong Kong, 999077, China. steven.wang@cityu.edu.hk., Wang Z; Department of Mechanical Engineering, The Hong Kong Polytechnic University, Hong Kong, 999077, China. zk.wang@polyu.edu.hk., Feng ZQ; School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China. fengzhangqi1981@163.com.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Dec 16; Vol. 14 (1), pp. 8386. Date of Electronic Publication: 2023 Dec 16.
DOI: 10.1038/s41467-023-44065-6
Abstrakt: Bioelectronic medicine is a rapidly growing field where targeted electrical signals can act as an adjunct or alternative to drugs to treat neurological disorders and diseases via stimulating the peripheral nervous system on demand. However, current existing strategies are limited by external battery requirements, and the injury and inflammation caused by the mechanical mismatch between rigid electrodes and soft nerves. Here we report a wireless, leadless, and battery-free ferroelectret implant, termed NeuroRing, that wraps around the target peripheral nerve and demonstrates high mechanical conformability to dynamic motion nerve tissue. As-fabricated NeuroRing can act as an ultrasound receiver that converts ultrasound vibrations into electrostimulation pulses, thus stimulating the targeted peripheral nerve on demand. This capability is demonstrated by the precise modulation of the sacral splanchnic nerve to treat colitis, providing a framework for future bioelectronic medicines that offer an alternative to non-specific pharmacological approaches.
(© 2023. The Author(s).)
Databáze: MEDLINE
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