Long-term follow-up results of a pilot study for nodular basal cell carcinoma with PDT using partial home treatment protocol.

Autor: Salvio AG; Skin Department of Amaral Carvalho Hospital, Jaú, Brazil; Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, Brazil. Electronic address: gasalvio@hotmail.com., Stringasci MD; Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, Brazil., Requena MB; Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, Brazil., Fregolenti BA; Skin Department of Amaral Carvalho Hospital, Jaú, Brazil., Medeiro MMDC; Skin Department of Amaral Carvalho Hospital, Jaú, Brazil., Santos RG; Skin Department of Amaral Carvalho Hospital, Jaú, Brazil., Bagnato VS; Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, Brazil; Department of Biomedical Engineering, Texas A&M University, TX, USA.
Jazyk: angličtina
Zdroj: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2024 Feb; Vol. 45, pp. 103930. Date of Electronic Publication: 2023 Dec 14.
DOI: 10.1016/j.pdpdt.2023.103930
Abstrakt: Significance: Evaluate a photodynamic therapy (PDT) protocol for low-risk basal cell carcinoma (BCC) treatment that requires less time spent at the hospital and is less painful.
Approach: Eight BCCs were selected, debulked, and received 20 % methyl aminolevulinate cream. After 3 h, the first irradiation was performed at the hospital (20 min, 150 J/cm 2 ). Then, the cream was re-applied, and a portable irradiation prototype was fixed to the skin around the lesion. After 1.5 h, the patients turned on the prototype for irradiation at home (for 2 h, totalizing 312 J/cm 2 ). Disease-free survival rate and pain score during irradiations were evaluated.
Results: The clearance at 30 days after PDT was 87.5 % by histological analysis. The mean follow-up was 21.5 months and the recurrence-free survival at 22 months was 75 %. The pain score was significantly lower at home.
Conclusions: A potentially less painful and more comfortable PDT treatment protocol with proven long-term efficiency is presented. A randomized clinical trial has been conducted to confirm these results.
Competing Interests: Declaration of Competing Interest There are no conflicts of interest.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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