Revisiting benzodiazepines (GABA Enhancers):A transdiagnostic and precision medicine approach.

Autor: Pallanti S; Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, USA; Institute of Neuroscience, Florence, Italy. Electronic address: stefanopallanti@yahoo.it., Zohar J; Chaim Sheba Medical Center, Tel Aviv, Israel., Kasper S; Center for Brain Research, Department of Molecular Neuroscience, Medical University of Vienna, Vienna, Austria., Möller HJ; Department of Psychiatry and Psychotherapy, University of München, Munich, Germany., Hollander E; Autism and Obsessive-Compulsive Spectrum Program, Psychiatric Research Institute at Montefiore-Einstein, Albert Einstein College of Medicine, USA.
Jazyk: angličtina
Zdroj: Journal of psychiatric research [J Psychiatr Res] 2024 Feb; Vol. 170, pp. 65-72. Date of Electronic Publication: 2023 Dec 02.
DOI: 10.1016/j.jpsychires.2023.11.042
Abstrakt: Since the mid 1980's, there has been an increased focus on the side effects of benzodiazepines (GABA enhancers), and as a result there has been a decrease in their use. We have systematically reviewed recent studies of GABA enhancers in psychiatry, and highlight evidence of their utility which may impact their negative conceptualization in clinical practice. We propose a new perspective on the appropriate use of these medications and describeclinical reasoning underpinning the use of benzodiazepine (GABA enhancers) based on their effect on specific receptors. A translational approach, involving a more comprehensive characterization of GABA receptors and their neuroscience-based mechanisms allows for a more precise use of this medication class. By adopting a precision person-centered approach, instead of a categorical approach, supports the prescribing of GABA enhancers when a cross-cutting transdiagnostic assessment shows anxiety symptoms associated with clinical impairment.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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