Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions.

Autor: Walker FC; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, United States of America., Derré I; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, United States of America. Electronic address: id8m@virginia.edu.
Jazyk: angličtina
Zdroj: Current opinion in microbiology [Curr Opin Microbiol] 2024 Feb; Vol. 77, pp. 102416. Date of Electronic Publication: 2023 Dec 15.
DOI: 10.1016/j.mib.2023.102416
Abstrakt: Chlamydia trachomatis is a common cause of sexually transmitted infections in humans with devastating sequelae. Understanding of disease on all scales, from molecular details to the immunology underlying pathology, is essential for identifying new ways of preventing and treating chlamydia. Infection models of various complexity are essential to understand all aspects of chlamydia pathogenesis. Cell culture systems allow for research into molecular details of infection, including characterization of the unique biphasic Chlamydia developmental cycle and the role of type-III-secreted effectors in modifying the host environment to allow for infection. Multicell type and organoid culture provide means to investigate how cells other than the infected cells contribute to the control of infection. Emerging comprehensive three-dimensional biomimetic systems may fill an important gap in current models to provide information on complex phenotypes that cannot be modeled in simpler in vitro models.
Competing Interests: Declaration of Competing Interest The authors declare no competing interests relevant to this article.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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