A glimpse into let-7e roles in human disorders; friend or foe?

Autor: Alshahrani SH; Medical Surgical Nursing Department, King Khalid University, Khamis Mushate, Saudi Arabia. Electronic address: alshahranishadia243@gmail.com., Yuliastanti T; STIKes Estu Utomo, Boyolali, Indonesia., Al-Dolaimy F; Al-Zahraa University for Women, Karbala, Iraq., Korotkova NL; I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation; Federal State Budgetary Educational Institution of Higher Education 'Privolzhsky Research Medical University' of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russian Federation., Rasulova I; School of Humanities, Natural & Social Sciences, New Uzbekistan University, 54 Mustaqillik Ave., Tashkent 100007, Uzbekistan; Department of Public Health, Samarkand State Medical University, Amir Temur Street 18, Samarkand, Uzbekistan., Almuala AF; College of Technical Engineering, the Islamic University, Najaf, Iraq; College of Technical Engineering, the Islamic University of Al Diwaniyah, Iraq; College of Technical Engineering, the Islamic University of Babylon, Iraq., Alsaalamy A; College of Technical Engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna 66002, Iraq., Ali SHJ; Department of Medical Laboratory, College of Health and Medical Technololgy, Al-Ayen University, Thi-Qar, Iraq., Alasheqi MQ; College of Nursing, National University of Science and Technology, Dhi Qar, Iraq., Mustafa YF; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul 41001, Iraq.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2024 Jan; Vol. 253, pp. 154992. Date of Electronic Publication: 2023 Nov 29.
DOI: 10.1016/j.prp.2023.154992
Abstrakt: MicroRNAs (miRNAs) have been linked to abnormal expression and regulation in a number of diseases, including cancer. Recent studies have concentrated on miRNA Let-7e's significance in precision medicine for cancer screening and diagnosis as well as its prognostic and therapeutic potential. Differential let-7e levels in bodily fluids have the possibility to enable early detection of cancer utilizing less-invasive techniques, reducing biopsy-related risks. Although Let-7e miRNAs have been described as tumor suppressors, it is crucial to note that there exists proof to support their oncogenic activity in vitro and in in vivo. Let-7e's significance in chemo- and radiation treatment decisions has also been demonstrated. Let-7e can also prevent the synthesis of proinflammatory cytokines in a number of degenerative disorders, including musculoskeletal and neurological conditions. For the first time, an overview of the significance of let-7e in the prevention, detection, and therapy of cancer and other conditions has been given in the current review. Additionally, we focused on the specific molecular processes that underlie the actions of let-7e, more particularly, on malignant cells.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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