Mucosal damage in pancreaticobiliary maljunction is stronger in the gallbladder than in the bile duct.

Autor: Kamakura M; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan., Uehara T; Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan. Electronic address: tuehara@shinshu-u.ac.jp., Muraki T; Department of Gastroenterology, North Alps Medical Center Azumi Hospital, Ikeda, Japan., Iwaya M; Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan., Asaka S; Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan; Department of Laboratory Medicine, Nagano Children's Hospital, Azumino, Japan., Nakajima T; Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan., Iwaya Y; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan., Nagaya T; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan., Yoshizawa T; Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan., Shimizu A; Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan., Kuraishi Y; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan., Ota H; Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan; Department of Biomedical Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan., Umemura T; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2024 Jan; Vol. 253, pp. 155011. Date of Electronic Publication: 2023 Dec 05.
DOI: 10.1016/j.prp.2023.155011
Abstrakt: Background: The frequency of gallbladder carcinoma is high in pancreaticobiliary maljunction (PBM), and the mechanism of carcinogenesis is not well understood.
Methods: The expression of γH2AX, the most sensitive marker for detecting DNA damage, was analyzed using immunohistochemistry in patients with PBM, in which the gallbladder and bile duct were simultaneously resected. Gallbladder and bile ducts were evaluated in non-neoplastic regions in 13 cases of PBM without cancer in the gallbladder and bile ducts.
Results: The median frequencies of γH2AX expression in the bile duct and gallbladder within the same case were 5.9% (range 1.7-12.05%) and 9.9% (range 2.8-25%), respectively, and were significantly higher in the gallbladder mucosa (P < 0.0004). γH2AX expression strongly correlated in the bile duct and gallbladder (r = 0.9436, P < 0.0001). PBM caused marked mucosal damage to the gallbladder.
Conclusions: Mucosal damage may be involved in carcinogenesis, which may be useful for predicting malignant transformation.
Competing Interests: Declaration of Competing Interest I declared on behalf of all authors that all authors have no conflicts of interest to declare.
(Copyright © 2023 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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