Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging.

Autor: Noroozi R; Doctoral School of Exact and Natural Sciences, Jagiellonian University, Krakow, Poland.; Johns Hopkins University School of Medicine, Baltimore, MD, USA., Rudnicka J; Doctoral School of Exact and Natural Sciences, Jagiellonian University, Krakow, Poland.; Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland., Pisarek A; Institute of Zoology and Biomedical Research of the Jagiellonian University, Krakow, Poland., Wysocka B; Central Forensic Laboratory of the Police, Warsaw, Poland., Masny A; Central Forensic Laboratory of the Police, Warsaw, Poland., Boroń M; Central Forensic Laboratory of the Police, Warsaw, Poland., Migacz-Gruszka K; Jagiellonian University Medical University, Krakow, Poland., Pruszkowska-Przybylska P; Department of Anthropology, University of Lodz, Lodz, Poland., Kobus M; Institute of Biological Sciences, Faculty of Biology and Environmental Sciences, Cardinal Stefan Wyszynski University in Warsaw, Warsaw, Poland., Lisman D; Department of Forensic Genetics, Pomeranian Medical University in Szczecin, Szczecin, Poland., Zielińska G; Department of Forensic Genetics, Pomeranian Medical University in Szczecin, Szczecin, Poland., Iljin A; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Lodz, Lodz, Poland., Wiktorska JA; MelissaMed M. Gauer, General Partnership, Lodz, Poland., Michalczyk M; Department of Sport Nutrition, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland., Kaczka P; Department of Sport Nutrition, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland., Krzysztofik M; Department of Sport Nutrition, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland., Sitek A; Department of Anthropology, University of Lodz, Lodz, Poland., Ossowski A; Department of Forensic Genetics, Pomeranian Medical University in Szczecin, Szczecin, Poland., Spólnicka M; Center for Forensic Science University of Warsaw, Warsaw, Poland., Branicki W; Institute of Zoology and Biomedical Research of the Jagiellonian University, Krakow, Poland.; Institute of Forensic Research, Krakow, Poland., Pośpiech E; Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland. ewelina.pospiech@pum.edu.pl.; Department of Forensic Genetics, Pomeranian Medical University in Szczecin, Szczecin, Poland. ewelina.pospiech@pum.edu.pl.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2024 Apr; Vol. 46 (2), pp. 2583-2604. Date of Electronic Publication: 2023 Dec 16.
DOI: 10.1007/s11357-023-01029-4
Abstrakt: DNA methylation (DNAm) clocks hold promise for measuring biological age, useful for guiding clinical interventions and forensic identification. This study compared the commonly used DNAm clocks, using DNA methylation and SNP data generated from nearly 1000 human blood or buccal swab samples. We evaluated different preprocessing methods for age estimation, investigated the association of epigenetic age acceleration (EAA) with various lifestyle and sociodemographic factors, and undertook a series of novel genome-wide association analyses for different EAA measures to find associated genetic variants. Our results highlighted the Skin&Blood clock with ssNoob normalization as the most accurate predictor of chronological age. We provided novel evidence for an association between the practice of yoga and a reduction in the pace of aging (DunedinPACE). Increased sleep and physical activity were associated with lower mortality risk score (MRS) in our dataset. University degree, vegetable consumption, and coffee intake were associated with reduced levels of epigenetic aging, whereas smoking, higher BMI, meat consumption, and manual occupation correlated well with faster epigenetic aging, with FitAge, GrimAge, and DunedinPACE clocks showing the most robust associations. In addition, we found a novel association signal for SOCS2 rs73218878 (p = 2.87 × 10 -8 ) and accelerated GrimAge. Our study emphasizes the importance of an optimized DNAm analysis workflow for accurate estimation of epigenetic age, which may influence downstream analyses. The results support the influence of genetic background on EAA. The associated SOCS2 is a member of the suppressor of cytokine signaling family known for its role in human longevity. The reported association between various risk factors and EAA has practical implications for the development of health programs to improve quality of life and reduce premature mortality associated with age-related diseases.
(© 2023. The Author(s), under exclusive licence to American Aging Association.)
Databáze: MEDLINE
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