Detailed role of microRNA-mediated regulation of PI3K/AKT axis in human tumors.

Autor: Al-Hawary SIS; Department of Business Administration, Al al-Bayt University, Mafraq, Jordan., Ruzibakieva M; Cell Therapy Department, Institute of Immunology and Human Genomics, Uzbekistan Academy of Science, Tashkent, Uzbekistan., Gupta R; Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India., Malviya J; Department of Life Sciences and Biological Sciences, IES University, Bhopal, Madhya Pradesh, India., Toama MA; College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq., Hjazi A; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia., Alkhayyat MRR; Department of Islamic Studies, College of Art, The Islamic University of Najaf, Najaf, Iraq.; Department of Islamic Studies, College of Art, The Islamic University of Babylon, Babylon, Iraq.; Department of Islamic Studies, College of Art, The Islamic University of Al Diwaniyah, Diwaniyah, Iraq., Alsaab HO; Department of Pharmaceutics and Pharmaceutical Technology, Taif University, Taif, Saudi Arabia., Hadi A; Department of Medical Laboratories Techniques, Imam Ja'afar Al-Sadiq University, Al-Muthanna, Iraq., Alwaily ER; Microbiology Research Group, Al-Ayen University, Thi-Qar, Iraq.
Jazyk: angličtina
Zdroj: Cell biochemistry and function [Cell Biochem Funct] 2024 Jan; Vol. 42 (1), pp. e3904. Date of Electronic Publication: 2023 Dec 16.
DOI: 10.1002/cbf.3904
Abstrakt: The regulation of signal transmission and biological processes, such as cell proliferation, apoptosis, metabolism, migration, and angiogenesis are greatly influenced by the PI3K/AKT signaling pathway. Highly conserved endogenous non-protein-coding RNAs known as microRNAs (miRNAs) have the ability to regulate gene expression by inhibiting mRNA translation or mRNA degradation. MiRNAs serve key role in PI3K/AKT pathway as upstream or downstream target, and aberrant activation of this pathway contributes to the development of cancers. A growing body of research shows that miRNAs can control the PI3K/AKT pathway to control the biological processes within cells. The expression of genes linked to cancers can be controlled by the miRNA/PI3K/AKT axis, which in turn controls the development of cancer. There is also a strong correlation between the expression of miRNAs linked to the PI3K/AKT pathway and numerous clinical traits. Moreover, PI3K/AKT pathway-associated miRNAs are potential biomarkers for cancer diagnosis, therapy, and prognostic evaluation. The role and clinical applications of the PI3K/AKT pathway and miRNA/PI3K/AKT axis in the emergence of cancers are reviewed in this article.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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