White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer's disease continuum.

Autor: Hirschfeld LR; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. pricelr@iu.edu.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. pricelr@iu.edu., Deardorff R; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Chumin EJ; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 47405, USA., Wu YC; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., McDonald BC; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Cao S; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Biostatistics and Health Data Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Risacher SL; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Yi D; Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, 03080, South Korea., Byun MS; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 03080, South Korea.; Department of Psychiatry, Seoul National University College of Medicine, Seoul, 03080, South Korea., Lee JY; Department of Psychiatry, Seoul National University College of Medicine, Seoul, 03080, South Korea.; Department of Neuropsychiatry, SMG-SNU Boramae Medical Center, Seoul, 07061, South Korea., Kim YK; Department of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, 07061, South Korea., Kang KM; Department of Radiology, Seoul National University Hospital, Seoul, 03080, South Korea., Sohn CH; Department of Radiology, Seoul National University Hospital, Seoul, 03080, South Korea., Nho K; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Indiana University School of Informatics and Computing, Indianapolis, IN, 46202, USA., Saykin AJ; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Lee DY; Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, 03080, South Korea.; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 03080, South Korea.; Department of Psychiatry, Seoul National University College of Medicine, Seoul, 03080, South Korea.
Jazyk: angličtina
Zdroj: Alzheimer's research & therapy [Alzheimers Res Ther] 2023 Dec 16; Vol. 15 (1), pp. 218. Date of Electronic Publication: 2023 Dec 16.
DOI: 10.1186/s13195-023-01369-5
Abstrakt: Background: White matter (WM) microstructural changes in the hippocampal cingulum bundle (CBH) in Alzheimer's disease (AD) have been described in cohorts of largely European ancestry but are lacking in other populations.
Methods: We assessed the relationship between CBH WM integrity and cognition or amyloid burden in 505 Korean older adults aged ≥ 55 years, including 276 cognitively normal older adults (CN), 142 with mild cognitive impairment (MCI), and 87 AD patients, recruited as part of the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's disease (KBASE) at Seoul National University.
Results: Compared to CN, AD and MCI subjects showed significantly higher RD, MD, and AxD values (all p-values < 0.001) and significantly lower FA values (left p ≤ 0.002, right p ≤ 0.015) after Bonferroni adjustment for multiple comparisons. Most tests of cognition and mood (p < 0.001) as well as higher medial temporal amyloid burden (p < 0.001) were associated with poorer WM integrity in the CBH after Bonferroni adjustment.
Conclusion: These findings are consistent with patterns of WM microstructural damage previously reported in non-Hispanic White (NHW) MCI/AD cohorts, reinforcing existing evidence from predominantly NHW cohort studies.
(© 2023. The Author(s).)
Databáze: MEDLINE
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