Interplay of body mass index and metabolic syndrome: association with physiological age from midlife to late-life.

Autor: Ler P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Solna, 171 65, Stockholm, Sweden. peggy.ler@ki.se., Ploner A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Solna, 171 65, Stockholm, Sweden., Finkel D; Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA.; Institute of Gerontology, Jönköping University, Jönköping, Sweden., Reynolds CA; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA., Zhan Y; School of Public Health, Sun Yat-Sen University, Shenzhen Campus, Shenzhen, Guandong, China., Jylhävä J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Solna, 171 65, Stockholm, Sweden.; Faculty of Social Sciences, Unit of Health Sciences and Gerontology Research Center, University of Tampere, Tampere, Finland., Dahl Aslan AK; School of Health Sciences, University of Skövde, Skövde, Sweden., Karlsson IK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Solna, 171 65, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2024 Apr; Vol. 46 (2), pp. 2605-2617. Date of Electronic Publication: 2023 Dec 16.
DOI: 10.1007/s11357-023-01032-9
Abstrakt: Obesity and metabolic syndrome (MetS) share common pathophysiological characteristics with aging. To better understand their interplay, we examined how body mass index (BMI) and MetS jointly associate with physiological age, and if the associations changed from midlife to late-life. We used longitudinal data from 1,825 Swedish twins. Physiological age was measured as frailty index (FI) and functional aging index (FAI) and modeled independently in linear mixed-effects models adjusted for chronological age, sex, education, and smoking. We assessed curvilinear associations of BMI and chronological age with physiological age, and interactions between BMI, MetS, and chronological age. We found a significant three-way interaction between BMI, MetS, and chronological age on FI (p-interaction = 0·006), not FAI. Consequently, we stratified FI analyses by age: < 65, 65-85, and ≥ 85 years, and modeled FAI across ages. Except for FI at ages ≥ 85, BMI had U-shaped associations with FI and FAI, where BMI around 26-28 kg/m 2 was associated with the lowest physiological age. MetS was associated with higher FI and FAI, except for FI at ages < 65, and modified the BMI-FI association at ages 65-85 (p-interaction = 0·02), whereby the association between higher BMI levels and FI was stronger in individuals with MetS. Age modified the MetS-FI association in ages ≥ 85, such that it was stronger at higher ages (p-interaction = 0·01). Low BMI, high BMI, and metabolic syndrome were associated with higher physiological age, contributing to overall health status among older individuals and potentially accelerating aging.
(© 2023. The Author(s).)
Databáze: MEDLINE
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