Effects of a mindfulness-based intervention and a health self-management programme on psychological well-being in older adults with subjective cognitive decline: Secondary analyses from the SCD-Well randomised clinical trial.

Autor: Schlosser M; Department of Psychology, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland.; Division of Psychiatry, Faculty of Brain Sciences, University College London, London, United Kingdom., Demnitz-King H; Division of Psychiatry, Faculty of Brain Sciences, University College London, London, United Kingdom., Barnhofer T; School of Psychology, University of Surrey, Surrey, United Kingdom., Collette F; GIGA-CRC In Vivo Imaging, University of Liège, Liège, Belgium.; Psychology and Neuroscience of Cognition Research Unit, Faculty of Psychology and Educational Sciences, University of Liège, Liège, Belgium., Gonneaud J; Normandie Univ, UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging of Neurological Disorders', Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen, France., Chételat G; Normandie Univ, UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging of Neurological Disorders', Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen, France., Jessen F; Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Kliegel M; Department of Psychology, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland., Klimecki OM; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland.; Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany., Lutz A; Eduwell team, Lyon Neuroscience Research Center Inserm U1028, CNRS UMR5292, Lyon 1 University, Lyon, France., Marchant NL; Division of Psychiatry, Faculty of Brain Sciences, University College London, London, United Kingdom.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Dec 15; Vol. 18 (12), pp. e0295175. Date of Electronic Publication: 2023 Dec 15 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0295175
Abstrakt: Objectives: Older adults with subjective cognitive decline (SCD) recruited from memory clinics have an increased risk of developing dementia and regularly experience reduced psychological well-being related to memory concerns and fear of dementia. Research on improving well-being in SCD is limited and lacks non-pharmacological approaches. We investigated whether mindfulness-based and health education interventions can enhance well-being in SCD.
Methods: The SCD-Well trial (ClinicalTrials.gov: NCT03005652) randomised 147 older adults with SCD to an 8-week caring mindfulness-based approach for seniors (CMBAS) or an active comparator (health self-management programme [HSMP]). Well-being was assessed at baseline, post-intervention, and 6-month post-randomisation using the Psychological Well-being Scale (PWBS), the World Health Organisation's Quality of Life (QoL) Assessment psychological subscale, and composites capturing meditation-based well-being dimensions of awareness, connection, and insight. Mixed effects models were used to assess between- and within-group differences in change.
Results: CMBAS was superior to HSMP on changes in connection at post-intervention. Within both groups, PWBS total scores, psychological QoL, and composite scores did not increase. Exploratory analyses indicated increases in PWBS autonomy at post-intervention in both groups.
Conclusion: Two non-pharmacological interventions were associated with only limited effects on psychological well-being in SCD. Longer intervention studies with waitlist/retest control groups are needed to assess if our findings reflect intervention brevity and/or minimal base rate changes in well-being.
Competing Interests: GC, FC, OMK, AL, and NLM have received research support from the EU’s Horizon 2020 research and innovation programme (grant agreement number 667696). GC has received research support from Inserm, Fondation d’entreprise MMA des Entrepreneurs du Futur, Fondation Alzheimer, Programme Hospitalier de Recherche Clinique, Région Normandie, Association France Alzheimer et maladies apparentées and Fondation Vaincre Alzheimer (all to Inserm), GC and AL have received research support and personal fees from Fondation d’entreprise MMA des Entrepreneurs du Futur. All other authors have declared that no competing interests exist.
(Copyright: © 2023 Schlosser et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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