Microglia promote remyelination independent of their role in clearing myelin debris.

Autor:	Baaklini CS; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Ho MFS; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Lange T; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Hammond BP; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Panda SP; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Zirngibl M; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Zia S; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Himmelsbach K; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Rana H; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Phillips B; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Antoszko D; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Ibanga J; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Lopez M; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Lee KV; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada., Keough MB; Division of Neurosurgery, Department of Surgery, University of Alberta, Edmonton, AB T6G 2R3, Canada., Caprariello AV; Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Cumming School of Medicine, Calgary, AB T2N 1N4, Canada., Kerr BJ; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada; Department of Anesthesiology & Pain Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada., Plemel JR; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2R3, Canada; Department of Medicine, Division of Neurology, University of Alberta, Edmonton, AB T6G 2R3, Canada. Electronic address: jrplemel@ualberta.ca.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2023 Dec 26; Vol. 42 (12), pp. 113574. Date of Electronic Publication: 2023 Dec 14.
DOI:	10.1016/j.celrep.2023.113574
Abstrakt:	Multiple sclerosis (MS) is an inflammatory disease characterized by myelin loss. While therapies exist to slow MS progression, no treatment currently exists for remyelination. Remyelination, linked to reduced disability in MS, relies on microglia and monocyte-derived macrophages (MDMs). This study aims to understand the role of microglia during remyelination by lineage tracing and depleting them. Microglial lineage tracing reveals that both microglia and MDMs initially accumulate, but microglia later dominate the lesion. Microglia and MDMs engulf equal amounts of inhibitory myelin debris, but after microglial depletion, MDMs compensate by engulfing more myelin debris. Microglial depletion does, however, reduce the recruitment and proliferation of oligodendrocyte progenitor cells (OPCs) and impairs their subsequent differentiation and remyelination. These findings underscore the essential role of microglia during remyelination and offer insights for enhancing this process by understanding microglial regulation of remyelination. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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