Long-term late effects in older gastric cancer survivors: Survival analysis using Cox hazard regression model by retrospective electronic health records.

Autor: Jeon M; College of Nursing and Brain Korea 21 FOUR Project, Yonsei University, Seoul, South Korea., Jang H; College of Nursing and Brain Korea 21 FOUR Project, Yonsei University, Seoul, South Korea., Jeon H; Department of Nursing, Graduate School, Yonsei University, Seoul, South Korea., Park CG; College of Nursing, University of Illinois, Chicago, IL, USA., Kim S; College of Nursing and Mo-Im Kim Nursing Research Institute, Yonsei University, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, South Korea. sangheekim@yuhs.ac.; Department of Artificial Intelligence, College of Computing, Yonsei University, Seoul, South Korea. sangheekim@yuhs.ac.
Jazyk: angličtina
Zdroj: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2023 Dec 15; Vol. 32 (1), pp. 29. Date of Electronic Publication: 2023 Dec 15.
DOI: 10.1007/s00520-023-08202-7
Abstrakt: Purpose: Because the population of older gastric cancer survivors (GCSs) is growing, understanding the long-term late effects experienced by these GCSs and their impact on survival outcomes is crucial for optimizing survivorship care. This study aims to identify and characterize these effects and investigate their association with survival outcomes.
Methods: A retrospective analysis of electronic health records was conducted on 9,539 GCSs diagnosed between 2011 and 2017. The GCSs were divided into two age groups (< 65 and ≥ 65 years) and the long-term late effects were categorized by age using Cox proportional hazard models. The impact of clinical factors and age-specific late effects on survival was evaluated in the older GCSs.
Results: Among the total GCSs, 37.6% were over and 62.4% were under 65 years of age. Significant differences between the age groups were observed in the cumulative hazard ratios (HRs) for iron and vitamin B12 levels and prognostic nutritional index (PNI) scores. In older GCSs, abnormal iron levels (HR 1.98, 95% CI 1.16-3.41, p = .013) and poor PNI scores (HR 1.59, 95% CI 1.03-2.47, p = .038) were associated with poorer survival outcomes. Additionally, being female was identified as a risk factor for lower survival rates (if male, HR 0.42, 95% CI 0.18-0.98, p = .045).
Conclusion: This study highlights the typical long-term late effects experienced by older GCSs. By tailoring survivorship care to address nutritional-, age-, and gender-related factors, the overall survival and quality of life of older GCSs can be improved.
(© 2023. The Author(s).)
Databáze: MEDLINE
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