Molecular pathways in the development of HPV-induced oropharyngeal cancer.

Autor:	Ullah MI; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka-72388, Aljouf, Saudi Arabia., Mikhailova MV; Department of Prosthetic Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. mariav.mikhailova@bk.ru., Alkhathami AG; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia., Carbajal NC; Doctor en Gestión Pública y Gobernabilidad, Docente en La Universidad Norbert Wiener, Lima, Perú. nasersadri416@gmail.com., Zuta MEC; Escuela de Posgrado, Universidad San Ignacio de Loyola, Lima, Peru., Rasulova I; School of Humanities, Natural & Social Sciences, New Uzbekistan University, 54 Mustaqillik Ave, 100007, Tashkent, Uzbekistan.; Department of Public Health, Tashkent Pediatric Medical Institute, Bogishamol Street 223, Tashkent, Uzbekistan., Najm MAA; Pharmaceutical Chemistry Department, College of Pharmacy, Al-Ayen University, Thi-Qar, Nasiriyah, Iraq., Abosoda M; College of Pharmacy, the Islamic University, Najaf, Iraq.; College of Pharmacy, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.; College of Pharmacy, the Islamic University of Babylon, Hillah, Iraq., Alsalamy A; College of Pharmacy, Imam Ja'afar Al-Sadiq University, Al-Muthanna, 66002, Iraq., Deorari M; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
Jazyk:	angličtina
Zdroj:	Cell communication and signaling : CCS [Cell Commun Signal] 2023 Dec 14; Vol. 21 (1), pp. 351. Date of Electronic Publication: 2023 Dec 14.
DOI:	10.1186/s12964-023-01365-0
Abstrakt:	Oropharyngeal cancer, a subset of head and neck cancer, is increasingly recognized as a unique clinical entity primarily influenced by high-risk human papillomavirus (HPV) infections, particularly HPV-16. This review delves into the viral life cycle of HPV-16 and its interactions with host cells, with a specific focus on the crucial roles played by the viral oncoproteins E6 and E7. These oncoproteins drive cellular proliferation by targeting critical tumor suppressor proteins like p53 and Rb, resulting in uncontrolled cell growth and genomic instability. Furthermore, the significance of epigenetic modifications induced by HPV-16 and their implications is important for cancer progression. This comprehensive review provides valuable insights into the intricate molecular landscape of HPV-induced oropharyngeal cancer, shedding light on the development of targeted therapies and preventive strategies for this emerging global health concern. Video Abstract. (© 2023. The Author(s).)
Databáze:	MEDLINE
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