Typhoid fever.

Autor: Meiring JE; Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi., Khanam F; International Centre for Diarrhoel Disease Research, Dhaka, Bangladesh., Basnyat B; Oxford University Clinical Research Unit, Kathmandu, Nepal., Charles RC; Massachusetts General Hospital, Harvard Medical School, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Crump JA; Centre for International Health, University of Otago, Dunedin, New Zealand., Debellut F; Center for Vaccine Innovation and Access, PATH, Geneva, Switzerland., Holt KE; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria, Australia., Kariuki S; Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya., Mugisha E; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA., Neuzil KM; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA., Parry CM; Department of Clinical Sciences and Education, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Pitzer VE; Department of Epidemiology of Microbial Diseases and Public Health Modelling Unit, Yale School of Public Health, Yale University, New Haven, CT, USA., Pollard AJ; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK., Qadri F; International Centre for Diarrhoel Disease Research, Dhaka, Bangladesh., Gordon MA; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi. magordon@liverpool.ac.uk.; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. magordon@liverpool.ac.uk.
Jazyk: angličtina
Zdroj: Nature reviews. Disease primers [Nat Rev Dis Primers] 2023 Dec 14; Vol. 9 (1), pp. 71. Date of Electronic Publication: 2023 Dec 14.
DOI: 10.1038/s41572-023-00480-z
Abstrakt: Typhoid fever is an invasive bacterial disease associated with bloodstream infection that causes a high burden of disease in Africa and Asia. Typhoid primarily affects individuals ranging from infants through to young adults. The causative organism, Salmonella enterica subsp. enterica serovar Typhi is transmitted via the faecal-oral route, crossing the intestinal epithelium and disseminating to systemic and intracellular sites, causing an undifferentiated febrile illness. Blood culture remains the practical reference standard for diagnosis of typhoid fever, where culture testing is available, but novel diagnostic modalities are an important priority under investigation. Since 2017, remarkable progress has been made in defining the global burden of both typhoid fever and antimicrobial resistance; in understanding disease pathogenesis and immunological protection through the use of controlled human infection; and in advancing effective vaccination programmes through strategic multipartner collaboration and targeted clinical trials in multiple high-incidence priority settings. This Primer thus offers a timely update of progress and perspective on future priorities for the global scientific community.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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