Nicotine Delivery and Changes in Withdrawal and Craving During Acute Electronic Cigarette, Heated Tobacco Product, and Cigarette Use Among a Sample of Black and White People Who Smoke.

Autor:	Leavens ELS; Department of Population Health, University of Kansas School of Medicine, Kansas City, KS, USA.; University of Kansas Comprehensive Cancer Center, Kansas City, KS, USA., Lambart L; Department of Population Health, University of Kansas School of Medicine, Kansas City, KS, USA., Diaz FJ; Department of Biostatistics and Data Science, University of Kansas School of Medicine, Kansas City, KS, USA., Wagener TL; Center for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH, USA., Ahluwalia JS; Department of Behavioral and Social Sciences, Brown University, Providence, RI, USA., Benowitz N; Clinical Pharmacology Research Program, Division of Cardiology, Department of Medicine, University of California, San Francisco, CA, USA., Nollen NL; Department of Population Health, University of Kansas School of Medicine, Kansas City, KS, USA.; University of Kansas Comprehensive Cancer Center, Kansas City, KS, USA.
Jazyk:	angličtina
Zdroj:	Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco [Nicotine Tob Res] 2024 May 22; Vol. 26 (6), pp. 780-784.
DOI:	10.1093/ntr/ntad247
Abstrakt:	Introduction: E-cigarettes and heated tobacco products (HTPs) may serve as potential options for harm reduction for smokers if they possess reward profiles similar to cigarettes. Little is known about the abuse liability of HTPs and e-cigarettes versus cigarettes in racial/ethnic minority smokers. Aims and Methods: Twenty-two nicotine-deprived people who smoke (black [n = 12] and white [n = 10]) completed three visits that included a standardized 10-puff bout followed by a 50-minute ad libitum use assessment with their usual brand cigarette (UBC), an e-cigarette, and HTP. Visits were completed in a randomized crossover design and were separated by a minimum 48-hour washout period. Assessments included plasma nicotine, Cmax, and reductions in craving and withdrawal. Results: UBC delivered significantly greater levels of nicotine compared to the e-cigarette (p < .001) and HTP (p < .01) during both the standardized and ad libitum sessions. HTP delivered more nicotine than the e-cigarette during the standardized puffing session (p = .047) but not the ad libitum session. Only craving during the standardized puffing session and not the ad libitum session showed significant differences across products (p < .001) such that UBC resulted in the greatest reduction followed by HTP and e-cigarette. Conclusions: Despite greater nicotine delivery from the UBC compared to e-cigarette and HTP, participants reported reductions in craving and withdrawal across products, particularly following ad libitum use. Implications: Use of participant's UBCs (UBC) resulted in greater nicotine delivery compared to both the e-cigarette and HTP. Despite this relative difference in nicotine delivery, participants reported reductions in craving and withdrawal across products, particularly following ad libitum use. These findings suggest that in this sample of black and white people who smoke, HTPs and e-cigarettes provided significant relief from negative symptoms that maintain smoking. (© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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