[Strychnine, in The Mysterious Affair at Styles: Blocking Glycinergic Synaptic Transmission].

Autor: Watanabe M; Hokkaido University Faculty of Medicine.
Jazyk: japonština
Zdroj: Brain and nerve = Shinkei kenkyu no shinpo [Brain Nerve] 2023 Dec; Vol. 75 (12), pp. 1285-1288.
DOI: 10.11477/mf.1416202523
Abstrakt: Strychnine is a poison that often appears in classical mysteries and has been used for medicine and various purposes. Clearly, its point of action is glycine receptors, and it inhibits glycinergic synaptic transmission. Because of its powerful stimulant effect on the nervous system, if taken orally, characteristic symptoms that are intense and agonizing, such as tonic convulsions, opisthotonus or posterior arch tension, and convulsive laughter, appear. These symptoms are linked to the pathological basis of tetanus, and the drug is an important topic ranging from neuroscience to medical care.
Databáze: MEDLINE