Gellan gum-dopamine mediated in situ synthesis of silver nanoparticles and development of nano/micro-composite injectable hydrogel with antimicrobial activity.

Autor: Biscari G; University of Palermo, Via Archirafi 32, Palermo 90123, Italy. Electronic address: giuseppina.biscari@unipa.it., Malkoch M; KTH Royal Institute of Technology, Teknikringen 56-58, Stockholm SE-100 44, Sweden. Electronic address: malkoch@kth.se., Fiorica C; University of Palermo, Via Archirafi 32, Palermo 90123, Italy. Electronic address: calogero.fiorica@unipa.it., Fan Y; KTH Royal Institute of Technology, Teknikringen 56-58, Stockholm SE-100 44, Sweden. Electronic address: yanmiao@kth.se., Palumbo FS; University of Palermo, Via Archirafi 32, Palermo 90123, Italy. Electronic address: fabiosalvatore.palumbo@unipa.it., Indelicato S; University of Palermo, Via Archirafi 32, Palermo 90123, Italy. Electronic address: serena.indelicato@unipa.it., Bongiorno D; University of Palermo, Via Archirafi 32, Palermo 90123, Italy. Electronic address: david.bongiorno@unipa.it., Pitarresi G; University of Palermo, Via Archirafi 32, Palermo 90123, Italy. Electronic address: giovanna.pitarresi@unipa.it.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Feb; Vol. 258 (Pt 1), pp. 128766. Date of Electronic Publication: 2023 Dec 13.
DOI: 10.1016/j.ijbiomac.2023.128766
Abstrakt: Infected skin wounds represent a serious health threat due to the long healing process and the risk of colonization by multi-drug-resistant bacteria. Silver nanoparticles (AgNPs) have shown broad-spectrum antimicrobial activity. This study introduces a novel approach to address the challenge of infected skin wounds by employing gellan gum-dopamine (GG-DA) as a dual-functional agent, serving both as a reducing and capping agent, for the in situ green synthesis of silver nanoparticles. Unlike previous methods, this work utilizes a spray-drying technique to convert the dispersion of GG-DA and AgNPs into microparticles, resulting in nano-into-micro systems (AgNPs@MPs). The microparticles, with an average size of approximately 3 μm, embed AgNPs with a 13 nm average diameter. Furthermore, the study explores the antibacterial efficacy of these AgNPs@MPs directly and in combination with other materials against gram-positive and gram-negative bacteria. The versatility of the antimicrobial material is showcased by incorporating the microparticles into injectable hydrogels. These hydrogels, based on oxidized Xanthan Gum (XGox) and a hyperbranched synthetic polymer (HB10K-G5-alanine), are designed with injectability and self-healing properties through Shiff base formation. The resulting nano-into-micro-into-macro hybrid hydrogel emerges as a promising biomedical solution, highlighting the multifaceted potential of this innovative approach in wound care and infection management.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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