Male breast cancer: No evidence for mosaic BRCA1 promoter methylation involvement.

Autor: Schwartz M; Department of genetics, Curie Institute, Paris, France; UMR3244, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France. Electronic address: mathias.schwartz@curie.fr., Ibadioune S; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Vacher S; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Villy MC; Department of genetics, Curie Institute, Paris, France; Université Paris Cité, Paris, France., Trabelsi-Grati O; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Le Gall J; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Caputo SM; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Delhomelle H; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Warcoin M; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Moncoutier V; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Bourneix C; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Boutry-Kryza N; Service de génétique, Hospices Civils de Lyon, Lyon, France., De Pauw A; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Stern MH; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France; DNA Repair and Uveal Melanoma (D.R.U.M.), Inserm U830, Paris, France., Buecher B; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Mouret-Fourme E; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Colas C; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Stoppa-Lyonnet D; Department of genetics, Curie Institute, Paris, France; Université Paris Cité, Paris, France; DNA Repair and Uveal Melanoma (D.R.U.M.), Inserm U830, Paris, France., Masliah-Planchon J; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Golmard L; Department of genetics, Curie Institute, Paris, France; Paris Sciences & Lettres Research University, Paris, France., Bieche I; Department of genetics, Curie Institute, Paris, France; Université Paris Cité, Paris, France.
Jazyk: angličtina
Zdroj: Breast (Edinburgh, Scotland) [Breast] 2024 Feb; Vol. 73, pp. 103620. Date of Electronic Publication: 2023 Dec 10.
DOI: 10.1016/j.breast.2023.103620
Abstrakt: Breast cancers (BC) are rare in men and are often caused by constitutional predisposing factors. In women, mosaic BRCA1 promoter methylations (MBPM) are frequent events, detected in 4-8% of healthy subjects. This constitutional epimutation increases risk of early-onset and triple-negative BC. However, the role of MBPM in male BC predisposition has never been assessed. We screened 40 blood samples from men affected by BC, and performed extensive tumour analysis on MBPM-positive patients. We detected two patients carrying MBPM. Surprisingly, tumour analysis revealed that neither of these two male BCs were caused by the constitutional BRCA1 epimutations carried by the patients.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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