High prevalence and genetic diversity of Treponema paraluisleporidarum isolates in European lagomorphs.

Autor:	Knauf S; Institute of International Animal Health/One Health, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health , Greifswald, Germany.; Infection Biology Unit, Deutsches Primatenzentrum GmbH, Leibniz Institute for Primate Research , Göttingen, Germany.; Professorship for International Animal Health/One Health, Faculty of Veterinary Medicine, Justus Liebig University , Giessen, Germany., Hisgen L; Institute of International Animal Health/One Health, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health , Greifswald, Germany.; Infection Biology Unit, Deutsches Primatenzentrum GmbH, Leibniz Institute for Primate Research , Göttingen, Germany., Ågren EO; Department of Pathology and Wildlife Diseases, National Veterinary Institute , Uppsala, Sweden., Barlow AM; Wildlife Network for Disease Surveillance, Bristol Veterinary School , Langford, Somerset, United Kingdom., Faehndrich M; Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hanover, Foundation , Hanover, Germany., Voigt U; Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hanover, Foundation , Hanover, Germany., Fischer L; Wildlife Research Institute, State Agency for Nature, Environment and Consumer Protection North Rhine-Westphalia , Bonn, Germany., Grillová L; Department of Biology, Masaryk University , Brno, Czechia., Hallmaier-Wacker LK; Infection Biology Unit, Deutsches Primatenzentrum GmbH, Leibniz Institute for Primate Research , Göttingen, Germany., Kik MJL; Pathology Division, Department of Biomedical Health Sciences, Veterinary Medicine, Utrecht University , Utrecht, the Netherlands., Klink JC; Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hanover, Foundation , Hanover, Germany., Křenová J; Department of Biology, Masaryk University , Brno, Czechia., Lavazza A; Department of Animal Health and Welfare - Virology Unit, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna , Brescia, Italy., Lüert S; Institute of International Animal Health/One Health, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health , Greifswald, Germany.; Infection Biology Unit, Deutsches Primatenzentrum GmbH, Leibniz Institute for Primate Research , Göttingen, Germany., Nováková M; Department of Biology, Masaryk University , Brno, Czechia., Čejková D; Department of Biomedical Engineering, Brno University of Technology , Brno, Czechia., Pacioni C; Department of Environment, Land, Water and Planning, Arthur Rylah Institute for Environmental Research , Heidelberg, Victoria, Australia.; Environmental and Conservation Sciences, Murdoch University , Murdoch, Australia., Trogu T; Department of Animal Health and Welfare - Virology Unit, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna , Brescia, Italy., Šmajs D; Department of Biology, Masaryk University , Brno, Czechia., Roos C; Primate Genetics Laboratory, Deutsches Primatenzentrum GmbH, Leibniz Institute for Primate Research , Göttingen, Germany.; Gene Bank of Primates, Deutsches Primatenzentrum GmbH, Leibniz Institute for Primate Research , Göttingen, Germany.
Jazyk:	angličtina
Zdroj:	Microbiology spectrum [Microbiol Spectr] 2024 Jan 11; Vol. 12 (1), pp. e0177423. Date of Electronic Publication: 2023 Dec 14.
DOI:	10.1128/spectrum.01774-23
Abstrakt:	Importance: Syphilis is an ancient disease of humans and lagomorphs caused by two distinct but genetically closely related bacteria (>98% sequence identity based on the whole genome) of the genus Treponema . While human syphilis is well studied, little is known about the disease in the lagomorph host. Yet, comparative studies are needed to understand mechanisms in host-pathogen coevolution in treponematoses. Importantly, Treponema paraluisleporidarum -infected hare populations provide ample opportunity to study the syphilis-causing pathogen in a naturally infected model population without antibiotic treatment, data that cannot be obtained from syphilis infection in humans. We provide data on genetic diversity and are able to highlight various types of repetitions in one of the two hypervariable regions at the tp0548 locus that have not been described in the human syphilis-causing sister bacterium Treponema pallidum subsp. pallidum . Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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