Association between culture and the preference for, and perceptions of, 11 routes of medicine administration: A survey in 21 countries and regions.

Autor:	Murdan S; UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK., Wei L; UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK., van Riet-Nales DA; Medicines Evaluation Board Utrecht, the Netherlands., Gurmu AE; Department of Pharmacognosy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia., Usifoh SF; Department of Clinical Pharmacy & Pharmacy Practice, Faculty of Pharmacy, University of Benin, Benin City, Nigeria., Tăerel AE; Faculty of Pharmacy, University of Medicine and Pharmacy 'Carol Davila', Bucharest, Romania., Yıldız-Peköz A; Dept. of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, Turkey., Krajnović D; Department of Social Pharmacy and Pharmaceutical Legislation, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia., Azzopardi LM; Department of Pharmacy, Faculty of Medicine and Surgery University of Malta, Msida, Malta., Brock T; Department of Clinical Pharmacy, UCSF School of Pharmacy, UCSF Box 0622, 521 Parnassus Ave, San Francisco 94143, USA., Fernandes AI; Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Caparica, Almada, Portugal., Dos Santos ALS; Department of General Microbiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil., Anto BP; Dept of Clinical & Social Pharmacy, Faculty of Pharmacy & Pharmaceutical sciences, KNUST, Kumasi, Ghana., Vallet T; ClinSearch, 110 Avenue Pierre Brossolette, 92240 Malakoff, France., Lee EE; Seoul National University College of Pharmacy, Republic of Korea., Jeong KH; College of Pharmacy, Chung-Ang University, Republic of Korea., Akel M; School of Pharmacy, Lebanese International University, Lebanon.; Inspect-Lb (Institut National De Santé Publique, D'épidémiologie Clinique Et De Toxicologie-Liban), Beirut, Lebanon., Tam E; Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong., Volmer D; Institute of Pharmacy, Faculty of Medicine, University of Tartu, 50411 Tartu, Estonia., Douss T; Faculty of Pharmacy of Monastir, Tunisia., Shukla S; Symbiosis Statistical Institute, Symbiosis International (Deemed University), Pune, India., Yamamura S; Department of Biostatistics, Faculty of Pharmaceutical Sciences, Josai International University, Togane, Chiba, Japan., Lou X; Zhejiang University, China., van Riet BHG; Department of Radiotherapy, Netherlands Cancer Institute (at the time of participant recruitment in the Netherlands: MEB and VU University Medical Center), Amsterdam, the Netherlands., Usifoh CO; Department of Clinical Pharmacy & Pharmacy Practice, Faculty of Pharmacy, University of Benin, Benin City, Nigeria., Duwiejua M; Dept of Clinical & Social Pharmacy, Faculty of Pharmacy & Pharmaceutical sciences, KNUST, Kumasi, Ghana., Ruiz F; ClinSearch, 110 Avenue Pierre Brossolette, 92240 Malakoff, France., Furnham A; Dept Leadership and Orgnaisational Behaviour, Norwegian Business School, Norway.
Jazyk:	angličtina
Zdroj:	Exploratory research in clinical and social pharmacy [Explor Res Clin Soc Pharm] 2023 Nov 26; Vol. 12, pp. 100378. Date of Electronic Publication: 2023 Nov 26 (Print Publication: 2023).
DOI:	10.1016/j.rcsop.2023.100378
Abstrakt:	Medicines can be taken by various routes of administration. These can impact the effects and perceptions of medicines. The literature about individuals' preferences for and perceptions of the different routes of administration is sparse, but indicates a potential influence of culture. Our aim was to determine: (i) any association between one's culture and one's preferred route of medicine administration and (ii) individual perceptions of pain, efficacy, speed of action and acceptability when medicines are swallowed or placed in the mouth, under the tongue, in the nose, eye, ear, lungs, rectum, vagina, on the skin, or areinjected. A cross-sectional, questionnaire-based survey of adults was conducted in 21 countries and regions of the world, namely, Tunisia, Ghana, Nigeria, Turkey, Ethiopia, Lebanon, Malta, Brazil, Great Britain, United States, India, Serbia, Romania, Portugal, France, Netherlands, Japan, South Korea, Hong Kong, mainland China and Estonia, using the Inglehart-Welzel cultural map to ensure coverage across all cultures. Participants scored the pain/discomfort, efficacy, speed of onset and acceptability of the different routes of medicine administration and stated their preferred route. Demographic information was collected. A total of 4435 participants took part in the survey. Overall, the oral route was the most preferred route, followed by injection, while the rectal route was the least preferred. While the oral route was the most preferred in all cultures, the percentage of participants selecting this route varied, from 98% in Protestant Europe to 50% in the African-Islamic culture. A multinomial logistic regression model revealed a number of predictors for the preferred route. Injections were favoured in the Baltic, South Asia, Latin America and African-Islamic cultures while dermal administration was favoured in Catholic Europe, Baltic and Latin America cultures. A marked association was found between culture and the preference for, and perceptions of the different routes by which medicines are taken. This applied to even the least favoured routes (vaginal and rectal). Only women were asked about the vaginal route, and our data shows that the vaginal route was slightly more popular than the rectal one. Competing Interests: Authors declare that they have no conflict of interest. (© 2023 The Authors.)
Databáze:	MEDLINE
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