Applications of Innovation Technologies for Personalized Cancer Medicine: Stem Cells and Gene-Editing Tools.

Autor:	Hasanzadeh A; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran 14535, Iran.; Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran 14535, Iran.; Advances Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran 14535, Iran., Ebadati A; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran 14535, Iran.; Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran 14535, Iran.; Advances Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran 14535, Iran., Dastanpour L; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran 14535, Iran.; Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran 14535, Iran.; Advances Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran 14535, Iran., Aref AR; Department of Medical Oncology and Belfer Center for Applied Cancer Science, Dana Farber Cancer Institute, Boston, Massachusetts 02115, United States., Sahandi Zangabad P; Monash Institute of Pharmaceutical Sciences, Department of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Melbourne, Victoria 3052, Australia., Kalbasi A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, United States., Dai X; School of Biotechnology, Jiangnan University, Wuxi 214122, China.; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China.; Jiangsu Provincial Research Center for Bioactive Product Processing Technology, Jiangnan University, Wuxi 214122, China., Mehta G; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.; Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.; Precision Health, University of Michigan, Ann Arbor, Michigan 48105, United States., Ghasemi A; Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran 14535, Iran.; Department of Materials Science and Engineering, Sharif University of Technology, Tehran 14588, Iran., Fatahi Y; Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14166, Iran.; Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14166, Iran.; Universal Scientific Education and Research Network (USERN), Tehran 14166, Iran., Joshi S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States., Hamblin MR; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa.; Radiation Biology Research Center, Iran University of Medical Sciences, Tehran 14535, Iran., Karimi M; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran 14535, Iran.; Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran 14535, Iran.; Oncopathology Research Center, Iran University of Medical Sciences, Tehran 14535, Iran.; Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran 14166, Iran.; Applied Biotechnology Research Centre, Tehran Medical Science, Islamic Azad University, Tehran 14166, Iran.
Jazyk:	angličtina
Zdroj:	ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2023 Nov 14; Vol. 6 (12), pp. 1758-1779. Date of Electronic Publication: 2023 Nov 14 (Print Publication: 2023).
DOI:	10.1021/acsptsci.3c00102
Abstrakt:	Personalized medicine is a new approach toward safer and even cheaper treatments with minimal side effects and toxicity. Planning a therapy based on individual properties causes an effective result in a patient's treatment, especially in a complex disease such as cancer. The benefits of personalized medicine include not only early diagnosis with high accuracy but also a more appropriate and effective therapeutic approach based on the unique clinical, genetic, and epigenetic features and biomarker profiles of a specific patient's disease. In order to achieve personalized cancer therapy, understanding cancer biology plays an important role. One of the crucial applications of personalized medicine that has gained consideration more recently due to its capability in developing disease therapy is related to the field of stem cells. We review various applications of pluripotent, somatic, and cancer stem cells in personalized medicine, including targeted cancer therapy, cancer modeling, diagnostics, and drug screening. CRISPR-Cas gene-editing technology is then discussed as a state-of-the-art biotechnological advance with substantial impacts on medical and therapeutic applications. As part of this section, the role of CRISPR-Cas genome editing in recent cancer studies is reviewed as a further example of personalized medicine application. Competing Interests: The authors declare no competing financial interest. (© 2023 American Chemical Society.)
Databáze:	MEDLINE
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