Circadian regulation of physiology by disordered protein-protein interactions.

Autor: Sutton LB; Center for Biotechnology and Interdisciplinary Studies Rensselaer Polytechnic Institute, 110 8th St. Troy, NY, 12180, USA; Biological Sciences Department, Rensselaer Polytechnic Institute, 110 8th St. Troy, NY, 12180, USA., Hurley JM; Center for Biotechnology and Interdisciplinary Studies Rensselaer Polytechnic Institute, 110 8th St. Troy, NY, 12180, USA; Biological Sciences Department, Rensselaer Polytechnic Institute, 110 8th St. Troy, NY, 12180, USA. Electronic address: hurlej2@rpi.edu.
Jazyk: angličtina
Zdroj: Current opinion in structural biology [Curr Opin Struct Biol] 2024 Feb; Vol. 84, pp. 102743. Date of Electronic Publication: 2023 Dec 13.
DOI: 10.1016/j.sbi.2023.102743
Abstrakt: Cellular circadian clocks, the molecular timers that coordinate physiology to the day/night cycle across the domains of life, are widely regulated by disordereddisordered protein interactions. Here, we review the disordered-disordered protein interactions in the circadian clock of Neurospora crassa (N. crassa), a filamentous fungus which is a model organism for clocks in higher eukaryotes. We focus on what is known about the interactions between the intrinsically disordered core negative arm protein FREQUENCEY (FRQ), the other proteins comprising the transcription-translation feedback loop, and the proteins that control output. We compare and contrast this model with other models of eukaryotic clocks, illustrating that protein disorder is a conserved and essential mechanism in the maintenance of circadian clock across species.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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