Engineering Saccharomyces cerevisiae for application in integrated bioprocessing biorefineries.

Autor: Minnaar LS; Department of Biotechnology, University of the Western Cape, Bellville, South Africa., Kruger F; Department of Biotechnology, University of the Western Cape, Bellville, South Africa., Fortuin J; Department of Biotechnology, University of the Western Cape, Bellville, South Africa., Hoffmeester LJ; Department of Biotechnology, University of the Western Cape, Bellville, South Africa., den Haan R; Department of Biotechnology, University of the Western Cape, Bellville, South Africa. Electronic address: rdenhaan@uwc.ac.za.
Jazyk: angličtina
Zdroj: Current opinion in biotechnology [Curr Opin Biotechnol] 2024 Feb; Vol. 85, pp. 103030. Date of Electronic Publication: 2023 Dec 12.
DOI: 10.1016/j.copbio.2023.103030
Abstrakt: After decades of research and development, no organism - natural or engineered - has been described that can produce commodity products through direct microbial conversion to meet industry demands in terms of rates and yields. Variation in lignocellulosic biomass (LCB) feedstocks, the lack of a widely applicable pretreatment method, and the limited economic value of energy products further complicates second-generation biofuel production. Nevertheless, the emergence of advanced genomic editing tools and a more comprehensive understanding of yeast metabolic systems offer promising avenues for the creation of yeast strains tailored to LCB biorefineries. Here, we discuss recent advances toward developing yeast strains that could convert different LCB fractions into a series of economically viable commodity products in a biorefinery.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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