An energy costly architecture of neuromodulators for human brain evolution and cognition.

Autor:	Castrillon G; Department of Neuroradiology at Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Research Group in Medical Imaging, SURA Ayudas Diagnósticas, Medellin, Colombia.; Department of Neuroradiology at Uniklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany., Epp S; Department of Neuroradiology at Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität München, Munich, Germany., Bose A; Department of Neuroradiology at Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität München, Munich, Germany., Fraticelli L; Department of Neuroradiology at Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität München, Munich, Germany., Hechler A; Department of Neuroradiology at Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität München, Munich, Germany., Belenya R; Department of Neuroradiology at Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität München, Munich, Germany., Ranft A; Department of Anesthesiology and Intensive Care Medicine at Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Yakushev I; Department of Nuclear Medicine at Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Utz L; Department of Neuroradiology at Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Sundar L; Quantitative Imaging and Medical Physics Team, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria., Rauschecker JP; Center for Neuroengineering, Georgetown University, Washington, DC, USA.; Institute for Advanced Study, Technical University of Munich, Munich, Germany., Preibisch C; Department of Neuroradiology at Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Department of Neurology at Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Kurcyus K; Department of Neuroradiology at Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Riedl V; Department of Neuroradiology at Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Department of Neuroradiology at Uniklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2023 Dec 15; Vol. 9 (50), pp. eadi7632. Date of Electronic Publication: 2023 Dec 13.
DOI:	10.1126/sciadv.adi7632
Abstrakt:	In comparison to other species, the human brain exhibits one of the highest energy demands relative to body metabolism. It remains unclear whether this heightened energy demand uniformly supports an enlarged brain or if specific signaling mechanisms necessitate greater energy. We hypothesized that the regional distribution of energy demands will reveal signaling strategies that have contributed to human cognitive development. We measured the energy distribution within the brain functional connectome using multimodal brain imaging and found that signaling pathways in evolutionarily expanded regions have up to 67% higher energetic costs than those in sensory-motor regions. Additionally, histology, transcriptomic data, and molecular imaging independently reveal an up-regulation of signaling at G-protein-coupled receptors in energy-demanding regions. Our findings indicate that neuromodulator activity is predominantly involved in cognitive functions, such as reading or memory processing. This study suggests that an up-regulation of neuromodulator activity, alongside increased brain size, is a crucial aspect of human brain evolution.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu