The Inhibitory Activity of Lactobacillus plantarum Supernatant against Enterobacteria, Campylobacter, and Tumor Cells.

Autor: Danilova TA; Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia. dansen@inbox.ru., Adzhieva AA; Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia., Mezentseva MV; Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia., Suetina IA; Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia., Danilina GA; Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia., Minko AG; Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia., Dmitrieva ML; Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia., Zhukhovitsky VG; Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.; Department of Clinical and Laboratory Diagnosis with Laboratory Immunology Course, Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Nov; Vol. 176 (1), pp. 64-67. Date of Electronic Publication: 2023 Dec 13.
DOI: 10.1007/s10517-023-05969-x
Abstrakt: Cell-free supernatant of Lactobacillus plantarum exhibit a strong antimicrobial effect against a number of pathogenic enterobacteria (E. coli, Shigella flexneri, Salmonella typhimurium, Proteus mirabilis, and Campylobacter jejuni). The degree of growth inhibition in broth culture reached a high level for all tested bacteria. The highest rates were noted for P. mirabilis (by 13 times) and the lowest for S. flexneri (by 5 times) and C. jejuni (by 4.5 times). Significant antiproliferative effect of the supernatant on cells of tumor-derived epithelial cell lines was shown. The highest degree of inhibition (by 22 times) was observed for HT-29 cells (colon carcinoma). Thus, inclusion of probiotics in traditional treatment schemes can increase the effectiveness of antibacterial and antitumor drug therapy.
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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