Anti-Inflammatory Effect of Technologically Processed Antibodies to the Molecules of the Major Histocompatibility Complex in a Model of Acute Inflammation In Vivo.

Autor: Petrova NV; Research Institute of General Pathology and Pathophysiology, Moscow, Russia. nataliyaapetrova89@gmail.com.; LLC 'MATERIA MEDICA HOLDING', Moscow, Russia. nataliyaapetrova89@gmail.com., Tarasov SA; Research Institute of General Pathology and Pathophysiology, Moscow, Russia.; LLC 'MATERIA MEDICA HOLDING', Moscow, Russia., Kiseleva EA; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Nov; Vol. 176 (1), pp. 68-71. Date of Electronic Publication: 2023 Dec 13.
DOI: 10.1007/s10517-023-05968-y
Abstrakt: The anti-inflammatory effect of technologically processed antibodies (TPA) to immune targets (MHC I and MHC II) was assessed in the carrageenan-induced rat paw edema model. The parameters "increase in edema" and "suppression of edema" significantly decreased (p<0.05) against the background of treatment with TPA and the reference drug indomethacin compared to the placebo group. The tested TPA produced an anti-inflammatory effect.
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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