Effect of Adrenoreceptor Stimulation on Peptidergic Regulation of Cardiac Activity in Newborn Rats.

Autor: Iskakov NG; Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia. nikitaiskakov1992@mail.ru.; Department of Medical and Biological Disciplines, Volga Region State University of Physical Culture, Sports and Tourism, Kazan, Republic of Tatarstan, Russia. nikitaiskakov1992@mail.ru., Anikina TA; Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia., Nikolaev TI; Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia., Krylova AV; Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia., Zefirov TL; Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Nov; Vol. 176 (1), pp. 9-13. Date of Electronic Publication: 2023 Dec 13.
DOI: 10.1007/s10517-023-05957-1
Abstrakt: We studied the effect of adrenoreceptor stimulation on the frequency of spontaneous activity and amplitude-time parameters of isometric contraction of the atrial myocardial strips from newborn rats, as well as the effect of Y receptor stimulation against the background of adrenoreceptor activation. After addition of Y 1,5 receptor agonist [Leu31, Pro34] NPY (10 -7 M), a tendency to a decrease in the effect of β 1,2 -adrenoreceptor agonist isoproterenol (10 -5 M) on the frequency of spontaneous activity and atrial myocardial contractility was observed. The age-related features of the effect of NPY on the frequency of spontaneous activity and contractility of myocardial strips from newborn and adult rats were revealed.
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Databáze: MEDLINE
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